PMID: 20632931Jul 17, 2010Paper

Lysine methylation of nonhistone proteins is a way to regulate their stability and function

Biochemistry. Biokhimii︠a︡
K S EgorovaL V Olenina

Abstract

This review is devoted to the dramatically expanding investigations of lysine methylation on nonhistone proteins and its functional importance. Posttranslational covalent modifications of proteins provide living organisms with ability to rapidly change protein activity and function in response to various stimuli. Enzymatic protein methylation at different lysine residues was evaluated in histones as a part of the "histone code". Histone methyltransferases methylate not only histones, but also many nuclear and cytoplasmic proteins. Recent data show that the regulatory role of lysine methylation on proteins is not restricted to the "histone code". This modification modulates activation, stabilization, and degradation of nonhistone proteins, thus influencing numerous cell processes. In this review we particularly focused on methylation of transcription factors and other nuclear nonhistone proteins. The methylated lysine residues serve as markers attracting nuclear "reader" proteins that possess different chromatin-modifying activities.

References

Feb 1, 1973·The Biochemical Journal·R H BrownD Boulter
Jun 1, 1973·The Biochemical Journal·R H Brown, D Boulter
May 11, 1982·Biochemistry·T SasagawaK Titani
Dec 1, 1994·Genetics·G PalumboS Pimpinelli
Apr 21, 1993·Biochimica Et Biophysica Acta·J CavalliusW C Merrick
Dec 15, 1995·Cell·D J MangelsdorfR M Evans
May 31, 1996·The Journal of Biological Chemistry·L S WrightF L Siegel
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Jan 19, 2000·Nature·B D Strahl, C D Allis
May 3, 2000·The Journal of Biological Chemistry·B PolevodaF Sherman
Aug 11, 2001·Science·T Jenuwein, C D Allis
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sang-Won LeeRichard D Smith
Sep 28, 2002·Nature·Helena Santos-RosaTony Kouzarides
Nov 29, 2002·The EMBO Journal·Lin-feng ChenWarner C Greene
Aug 15, 2003·Oncogene·Soumen ChakrabortyGiuseppina Nucifora
Jul 4, 1959·Nature·R P AMBLER, M W REES
Apr 22, 2004·Molecular Cell·Antigone KouskoutiIannis Talianidis
Jul 6, 2004·Nature Cell Biology·Ryuji HamamotoYusuke Nakamura
Oct 14, 2004·Endocrine Reviews·David Y LeeMichael R Stallcup
Oct 16, 2004·The Journal of Biological Chemistry·Debasis PatnaikSriharsa Pradhan
Nov 5, 2004·Nature·Sergei ChuikovDanny Reinberg

❮ Previous
Next ❯

Citations

Sep 27, 2012·Journal of Biomolecular NMR·Francois-Xavier TheilletPhilipp Selenko
Apr 24, 2012·Journal of the American Chemical Society·François-Xavier TheilletPhilipp Selenko
Sep 27, 2013·Molecular Biology of the Cell·Huiqing LiShao Jun Du
Nov 29, 2011·Protein Engineering, Design & Selection : PEDS·Michelle McClureStephen Barnes
Dec 19, 2012·Epigenomics·Wolfgang Fischle
Apr 1, 2013·Frontiers in Biology·Yiwei Lin, Binhua P Zhou
Aug 16, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Shao Jun DuJianshe Zhang
Sep 3, 2014·Chembiochem : a European Journal of Chemical Biology·Tatsuo YanagisawaShigeyuki Yokoyama
Apr 17, 2015·Multiple Sclerosis and Related Disorders·Peter J van den ElsenSandra Amor
Mar 10, 2015·Experimental Cell Research·Christian KaehlerSylvia Krobitsch
Apr 22, 2015·Nucleic Acids Research·Xing LiuWuhan Xiao
Sep 6, 2012·Nature Communications·Stefan KernstockPål Ø Falnes
Apr 10, 2014·Molecular Systems Biology·Sylvain LanouetteJean-François Couture
Mar 1, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mengxin CaiShaojun Du
Nov 22, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Arun MaheshArunkumar Dhayalan
Nov 3, 2010·Bioorganic & Medicinal Chemistry·Shuichi MoriTomoya Hirano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
R B MorelandH M Fried
European Journal of Human Genetics : EJHG
Judith J LucianiMarie-Geneviève Mattei
© 2021 Meta ULC. All rights reserved