Lysine nutrition in swine and the related monogastric animals: muscle protein biosynthesis and beyond

Shengfa F LiaoNaresh Regmi


Improving feed efficiency of pigs with dietary application of amino acids (AAs) is becoming increasingly important because this practice can not only secure the plasma AA supply for muscle growth but also protect the environment from nitrogen discharge with feces and urine. Lysine, the first limiting AA in typical swine diets, is a substrate for generating body proteins, peptides, and non-peptide molecules, while excess lysine is catabolized as an energy source. From a regulatory standpoint, lysine is at the top level in controlling AA metabolism, and lysine can also affect the metabolism of other nutrients. The effect of lysine on hormone production and activities is reflected by the change of plasma concentrations of insulin and insulin-like growth factor 1. Lysine residues in peptides are important sites for protein post-translational modification involved in epigenetic regulation of gene expression. An inborn error of a cationic AA transporter in humans can lead to a lysinuric protein intolerance condition. Dietary deficiency of lysine will impair animal immunity and elevate animal susceptibility to infectious diseases. Because lysine deficiency has negative impact on animal health and growth performance and it appears that...Continue Reading


Aug 1, 1976·The Journal of Nutrition·S H Chu, D M Hegsted
Mar 8, 1976·Biochemical and Biophysical Research Communications·Y F Chang
Oct 1, 1992·Journal of Animal Science·F M TomasM R Taverner
Jan 1, 1991·Annual Review of Nutrition·H P Broquist
May 1, 1990·The British Journal of Nutrition·D N SalterR J Elliott
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M GaticaJ E Allende
May 1, 1986·The American Journal of Clinical Nutrition·C N MeredithV R Young
Jun 1, 1987·Molecular and Cellular Endocrinology·J E ZullJ Jentoft
Aug 1, 1987·The Journal of Nutrition·M S Edmonds, D H Baker
Sep 1, 1966·The Journal of Clinical Investigation·J C FloydJ Rull
Dec 1, 1966·The Journal of Nutrition·B L O'Dell, J E Savage
Jan 1, 1984·Annual Review of Biochemistry·D R EyreP M Gallop
Jan 1, 1981·Current Medical Research and Opinion·A IsidoriM Cappa
Nov 1, 1981·Acta Endocrinologica·A C Andersson, S Henningsson
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·S NielsenM A Knepper
Feb 1, 1997·Journal of the American College of Nutrition·N W Flodin
Mar 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H P TilM I Willems
Jan 10, 1998·British Journal of Pharmacology·L LiaudetF Feihl
Jul 23, 1998·Critical Reviews in Biochemistry and Molecular Biology·P Van den SteenG Opdenakker
Nov 10, 1998·The Biochemical Journal·G Wu, S M Morris
Oct 20, 1999·Domestic Animal Endocrinology·B H Breier
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·J B van GoudoeverP J Reeds
Jun 8, 2001·Annual Review of Biochemistry·C M Pickart
Sep 26, 2002·Nutrition·Alberto Battezzati, Patrizia Riso
Jul 16, 2003·The Journal of Biological Chemistry·Joshua D Schnell, Linda Hicke
Mar 1, 1965·The Journal of Clinical Investigation·S O THIERL E ROSENBERG
Nov 19, 2003·Advanced Drug Delivery Reviews·K GelseT Aigner

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