PMID: 9440377Jan 24, 1998Paper

Lysine requirement of neonatal piglets receiving total parenteral nutrition as determined by oxidation of the indicator amino acid L-[1-14C]phenylalanine

The American Journal of Clinical Nutrition
J D HouseR O Ball

Abstract

The indicator amino acid oxidation technique was adapted for use during total parenteral nutrition. Twenty-one male Yorkshire piglets (3 d of age) fitted with jugular and femoral vein catheters, received total parenteral nutrition for 6 d. Total parenteral nutrition included 15 g amino acids .kg-1.d-1 (1.25 g lysine.kg-1.d-1), lipid + glucose (1.1 MJ.kg-1.d-1), and micronutrients. Piglets were randomly assigned to lysine intakes of 0.40, 0.55, 0.70, 0.85, 1.00, 1.15, or 1.30 g.kg-1.d-1 and received a 4-h primed, constant infusion of L-[1-14C]phenylalanine. Phenylalanine oxidation (% of dose) decreased significantly (P < 0.05) from 18.6% at the lowest lysine intake to 3.0% at a lysine intake of 0.85 g.kg-1.d-1. Further increases in lysine intake had no effect on phenylalanine oxidation. Regression analysis yielded a mean lysine requirement of 0.79 g.kg-1.d-1 and a safe intake (upper 95% confidence limit) of 0.84 g.kg-1.d-1. Changes in the plasma lysine concentration and phenylalanine oxidation rates supported this estimate. The indicator amino acid oxidation technique can now be used to determine amino acid requirements during total parenteral nutrition. This means that the ideal amino acid pattern for neonates receiving total p...Continue Reading

Citations

Aug 13, 1999·The American Journal of Physiology·J A BruntonR O Ball
Jun 6, 2000·The American Journal of Clinical Nutrition·D G BurrinP J Reeds
Feb 19, 2010·The American Journal of Clinical Nutrition·Karen P ChapmanPaul B Pencharz
Jan 18, 2013·The Journal of Nutrition·Karen P ChapmanPaul B Pencharz
Dec 1, 2006·Nutrition Research Reviews·D DardevetA D Cherrington
Jun 1, 2010·Animal : an International Journal of Animal Bioscience·J C Litten-BrownL Clarke
May 6, 2003·The Journal of Nutrition·Anna K ShovellerRonald O Ball
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·J A BruntonP B Pencharz
Sep 2, 2003·The Journal of Nutrition·Russell A ColemanDoug R Korver
Apr 20, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Douglas G Burrin, Teresa A Davis
Oct 26, 2001·Gastroenterology·S R van der SchoorP J Reeds
Dec 22, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Willemijn E CorpeleijnJohannes B van Goudoever

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