PMID: 11333843May 3, 2001Paper

Lysine requirements of healthy adult Indian subjects, measured by an indicator amino acid balance technique

The American Journal of Clinical Nutrition
Anura V KurpadV R Young

Abstract

In an earlier study, using a modification of the indicator amino acid oxidation approach, we concluded that the 1985 FAO/WHO/UNU-proposed lysine requirement of 12 mg x kg(-1) x d(-1) is likely inadequate to maintain body amino acid homeostasis in apparently healthy south Asian subjects and that our proposed requirement of 30 mg x kg(-1) x d(-1) is more appropriate. We assessed the lysine requirement in a similar population by using 4 test lysine intakes (12, 20, 28, and 36 mg x kg(-1) x d(-1)) with an indicator amino acid balance approach. Sixteen healthy male Indians were studied during each of 2 randomly assigned 8-d L-amino acid diets that supplied either 12 and 28 or 20 and 36 mg lysine. At 1800 on day 8, a 24-h intravenous [(13)C]leucine tracer-infusion protocol was conducted to assess leucine oxidation and daily leucine balance at each lysine intake. Mean 24-h leucine oxidation rates decreased significantly (P = 0.005) across different lysine intakes and were 104.1, 97.8, 87.3, and 87.3 mg x kg(-1) x d(-1) at intakes of 12, 20, 28, and 36 mg x kg(-1) x d(-1), respectively; mean 24-h leucine balances were 3.3, 9.1, 19.7, and 20.7 mg x kg(-1) x d(-1), respectively (P = 0.015, mixed-model analysis of variance). Oxidation and...Continue Reading

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Citations

Jan 16, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Cécile BosDaniel Tomé
Mar 11, 2003·Annual Review of Nutrition·Paul B Pencharz, Ronald O Ball
May 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Miro SmrigaNevin S Scrimshaw
Feb 18, 2019·Journal of Internal Medicine·W P T JamesP J Stover
Dec 12, 2003·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Jun 3, 2004·The Journal of Nutrition·William M Rand
Oct 31, 2012·The British Journal of Nutrition·Raja R Pillai, Anura V Kurpad
Oct 31, 2012·The British Journal of Nutrition·Rajavel ElangoPaul B Pencharz
Oct 31, 2012·The British Journal of Nutrition·Shane M RutherfurdPaul J Moughan
Oct 4, 2018·The Journal of Nutrition·Anura V Kurpad
Nov 28, 2001·The American Journal of Clinical Nutrition·A V KurpadV R Young
Apr 4, 2003·The Journal of Nutrition·Anura V Kurpad, Vernon R Young
Apr 30, 2003·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Aug 31, 2004·The British Journal of Nutrition·D Joe Millward
Nov 28, 2001·The American Journal of Clinical Nutrition·V R Young
Feb 3, 2005·Journal of Physiological Anthropology and Applied Human Science·Masakatsu NakadaYoshinori Nagasawa
May 22, 2007·The Journal of Nutrition·Daniel Tomé, Cécile Bos
Dec 25, 2002·The American Journal of Clinical Nutrition·William M RandVernon R Young
Jun 24, 2004·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Mar 29, 2003·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Oct 19, 2012·The Journal of Nutrition·Joost J G C van den BorneWalter J J Gerrits
Sep 27, 2002·The American Journal of Clinical Nutrition·Anura V KurpadVernon R Young
Feb 7, 2007·Journal of Physiological Anthropology·Masakatsu NakadaShunsuke Yamaji
Mar 28, 2002·The American Journal of Clinical Nutrition·Sudhir BorgonhaVernon R Young
Jan 10, 2006·The American Journal of Clinical Nutrition·Jean W-C HsuPaul B Pencharz
Jun 19, 2004·International Journal of Toxicology·Shoji TsubukuTakeshi Kimura
Jan 11, 2005·The American Journal of Clinical Nutrition·Cécile BosClaire Gaudichon
Jan 21, 2019·Amino Acids·Kohsuke HayamizuMakoto Nakano
May 18, 2018·The American Journal of Clinical Nutrition·Sarita DeviAnura V Kurpad
Dec 21, 2005·The Journal of Nutrition·Anura V KurpadJustin V Gnanou
Oct 2, 2020·The Journal of Nutrition·Kohsuke HayamizuMakoto Nakano
Dec 9, 2020·Critical Reviews in Food Science and Nutrition·Renuka Aggarwal, Kiran Bains
Sep 2, 2003·The Journal of Nutrition·Peter J Reeds, Peter J Garlick
Apr 7, 2004·Journal of Physiological Anthropology and Applied Human Science·Shunsuke YamajiMasakatsu Nakada
Dec 16, 2004·Journal of Physiological Anthropology and Applied Human Science·Masakatsu NakadaYoshinori Nagasawa
Aug 28, 2021·Frontiers in Nutrition·Dorothy K MuruguChrysantus M Tanga

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