Lysine63-linked ubiquitylation of PIN2 auxin carrier protein governs hormonally controlled adaptation of Arabidopsis root growth.

Proceedings of the National Academy of Sciences of the United States of America
Johannes LeitnerChristian Luschnig

Abstract

Cross-talk between plant cells and their surroundings requires tight regulation of information exchange at the plasma membrane (PM), which involves dynamic adjustments of PM protein localization and turnover to modulate signal perception and solute transport at the interface between cells and their surroundings. In animals and fungi, turnover of PM proteins is controlled by reversible ubiquitylation, which signals endocytosis and delivery to the cell's lytic compartment, and there is emerging evidence for related mechanisms in plants. Here, we describe the fate of Arabidopsis PIN2 protein, required for directional cellular efflux of the phytohormone auxin, and identify cis- and trans-acting mediators of PIN2 ubiquitylation. We demonstrate that ubiquitin acts as a principal signal for PM protein endocytosis in plants and reveal dynamic adjustments in PIN2 ubiquitylation coinciding with variations in vacuolar targeting and proteolytic turnover. We show that control of PIN2 proteolytic turnover via its ubiquitylation status is of significant importance for auxin distribution in root meristems and for environmentally controlled adaptations of root growth. Moreover, we provide experimental evidence indicating that PIN2 vacuolar sort...Continue Reading

References

Oct 6, 1997·The EMBO Journal·J M Galan, R Haguenauer-Tsapis
Oct 6, 1998·Annual Review of Biochemistry·A Hershko, A Ciechanover
Feb 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Iris OttenschlägerKlaus Palme
Apr 8, 2006·Science·Justyna WisniewskaJirí Friml
Apr 24, 2007·Nature Reviews. Molecular Cell Biology·Roger L Williams, Sylvie Urbé
Jun 26, 2007·The Plant Cell·Xiao-Jun YinAndreas Bachmair
Nov 9, 2007·Trends in Biochemical Sciences·Suraj SaksenaScott D Emr
May 1, 2008·Annual Review of Plant Biology·René Benjamins, Ben Scheres
Jun 14, 2008·Plant Physiology·Andrea GallavottiDavid Jackson
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jürgen Kleine-VehnJirí Friml
Dec 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Haopeng WangDario A A Vignali
Mar 28, 2009·Nature·Camilla Raiborg, Harald Stenmark
Feb 9, 2010·Trends in Cell Biology·Elsa LauwersBruno André
Jan 19, 2011·The Journal of Cell Biology·Daniel K Stringer, Robert C Piper
Jun 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Marie BarberonGrégory Vert
Aug 9, 2011·Current Opinion in Plant Biology·Francisca C ReyesMarisa S Otegui

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Citations

Jun 23, 2012·Plant Physiology·Dior R Kelley, Mark Estelle
May 3, 2016·Plants·Astrid Nagels DurandAlain Goossens
Dec 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ora HazakShaul Yalovsky
Aug 16, 2013·Journal of Integrative Plant Biology·Remko Offringa, Fang Huang
Oct 17, 2014·The Arabidopsis Book·Judy Callis
Jul 25, 2015·Molecular Plant·David G Robinson
Jun 6, 2015·Trends in Plant Science·Feifei YuQi Xie
Feb 26, 2015·Plant Science : an International Journal of Experimental Plant Biology·Suyeong JeongHye Ryun Woo
Mar 18, 2015·Molecular Plant·Enric Zelazny, Grégory Vert
Apr 29, 2015·Trends in Plant Science·Lusheng FanJinxing Lin
Aug 21, 2012·Plant Signaling & Behavior·Johannes LeitnerChristian Luschnig
Jul 28, 2012·Current Biology : CB·Angus S Murphy, Wendy Ann Peer
Dec 10, 2013·Current Biology : CB·Barbara KorbeiChristian Luschnig
Jan 11, 2014·Current Biology : CB·Michael Sauer, Jiří Friml
Jun 13, 2012·Developmental Biology·Cédric Finet, Yvon Jaillais
Apr 20, 2014·Frontiers in Plant Science·Charlotte K Walsh, Ari Sadanandom
Apr 30, 2016·Annual Review of Plant Biology·Julio Paez ValenciaMarisa S Otegui
Jul 5, 2016·Frontiers in Plant Science·Bhaskar SharmaTarun K Bhatt
Aug 9, 2016·Plant & Cell Physiology·Astrid Nagels DurandAlain Goossens
Dec 8, 2016·Molecular Plant Pathology·Bangjun Zhou, Lirong Zeng
May 17, 2017·The Plant Journal : for Cell and Molecular Biology·Yufang HanDongping Lu
Nov 15, 2014·Cells·Zoi ErpapazoglouRosine Haguenauer-Tsapis
Nov 8, 2017·International Journal of Molecular Sciences·Katarzyna RetzerChristian Luschnig
Feb 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Yuliya SalanenkaJiří Friml
Dec 2, 2017·The New Phytologist·Natali Romero-Barrios, Grégory Vert
Dec 9, 2017·Frontiers in Plant Science·Min NiJian-Zhong Liu
Jun 2, 2016·Development·Jorge E Salazar-HenaoWolfgang Schmidt
Aug 24, 2016·Nature Communications·Xiaolong LuBrian P Downes

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