PMID: 7020114Jun 1, 1981Paper

Lysis of growing yeast-form cells of Candida albicans by echinocandin: a cytological study

Sabouraudia
Antonio CassoneD Kerridge

Abstract

Yeast form cells of Candida albicans 6406 were treated with echinocandin, a new antifungal agent, which, in the absence of osmotic protection, provoked the lysis of exponentially growing cells. Lysis did not occur in stationary-phase cells and when protein synthesis was blocked. In intact cells, the synthesis of glucan, but not other important wall components, was partially inhibited. A cytological study of the effects of echinocandin at lytic doses (3.0 microgram ml-1) on osmotically protected yeast cells revealed a substantial thinning of the bud cell wall and derangement of its constitutive layers within 5-10 min, showing that the balance of wall growth was quickly and critically affected by the drug. Associated with this effect, a number of membranous bodies of myelin-like appearance were often seen in close proximity to the plasmamembrane of the emerging bud. Later during treatment (15 min onwards) membranous, convoluted bodies were detected in the nuclear and other intracytoplasmic membranes. Subsequent lytic events, unevenly distributed in cell population, eventually brought about complete lysis of the cell cytoplasmic structure. These results suggest that echinocandin may block a biosynthetic step during wall constructi...Continue Reading

References

Jul 1, 1979·European Journal of Biochemistry·B C BaguleyW Wehrli
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·E CundliffeJ Davies
Sep 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·E Cabib, V Farkas
Mar 1, 1969·Journal of General Microbiology·R Sentandreu, D H Northcote

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Citations

Mar 7, 2013·Applied Microbiology and Biotechnology·Tamás EmriIstván Pócsi
Sep 10, 2003·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Nicholas A KartsonisCameron M Douglas
May 1, 1989·Antimicrobial Agents and Chemotherapy·K A McIntyre, J N Galgiani
May 1, 1990·Antimicrobial Agents and Chemotherapy·C J Morrison, D A Stevens
Aug 1, 1995·Antimicrobial Agents and Chemotherapy·M B KurtzD Armstrong
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·J C BowmanC M Douglas
Mar 2, 2011·BMC Complementary and Alternative Medicine·Donatella PietrellaAnna Vecchiarelli
Sep 11, 2014·Natural Products and Bioprospecting·Muna Ali Abdalla, Josphat C Matasyoh
Oct 6, 2007·Insect Biochemistry and Molecular Biology·Denise M D BoutsHatisaburo Masuda
Jan 1, 1985·Microbiology and Immunology·H YamaguchiM Osumi
Sep 5, 2006·Biochemical and Biophysical Research Communications·Torsten NeuhofHans von Döhren
Jan 1, 1990·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·E DrouhetM C Prevost
Jan 1, 1992·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·L AngiolellaA Cassone
Jul 27, 2017·The Journal of Pharmacy and Pharmacology·Akash Patil, Soumyajit Majumdar
Jan 1, 2013·ISRN Preventive Medicine·M Anaul Kabir, Zulfiqar Ahmad
May 3, 2002·Drugs·Maher M BalkisMahmoud A Ghannoum
Mar 1, 1997·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·M B Kurtz, C M Douglas

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