PMID: 2123910Dec 1, 1990Paper

Lysis of plasminogen activator-resistant platelet-rich coronary artery thrombus with combined bolus injection of recombinant tissue-type plasminogen activator and antiplatelet GPIIb/IIIa antibody

Journal of the American College of Cardiology
T YasudaD Collen

Abstract

Resistance of coronary occlusive thrombus to thrombolytic therapy, found in some patients with acute myocardial infarction, may be due to the presence of platelet-rich coronary clot. Reperfusion therapy in such patients may require the development and evaluation of alternative strategies in animal models. Therefore, platelet-rich coronary artery thrombus was developed by excision, eversion (inside out) and reanastomosis of a 1 cm segment of the left circumflex coronary artery in anesthetized dogs maintained on heparin antiocoagulation. Blood flow was restored in 25 of 27 dogs. Thrombotic occlusion of the everted segment graft with primarily platelet-rich thrombus or thrombus containing platelet-rich and erythrocyte-rich zones, persisting for at least 30 min, occurred within 4.5 +/- 3.5 min (mean +/- SD) in 20 of these 25 dogs. In 5 of these 20 dogs (group I, control), stable occlusion, as monitored with an ultrasound flow probe and coronary angiography, was maintained during a 2 h observation period. In group II (n = 5), intravenous bolus injections of recombinant tissue-type plasminogen activator (rt-PA) at a dose of 0.45 mg/kg body weight at four 15 min intervals did not cause reperfusion in four dogs and produced cyclic repe...Continue Reading

References

Jun 1, 1987·The Journal of Clinical Investigation·J Loscalzo, D E Vaughan
Jan 1, 1988·Annual Review of Medicine·D CollenH K Gold
Dec 8, 1988·The New England Journal of Medicine
May 1, 1963·Clinica Chimica Acta; International Journal of Clinical Chemistry·C VERMYLENM VERSTRAETE

❮ Previous
Next ❯

Citations

Mar 1, 1997·Catheterization and Cardiovascular Diagnosis·O TopazG W Vetrovec
Jan 1, 1995·Journal of Thrombosis and Thrombolysis·C P Cannon, R Tracy
Jun 8, 2002·Current Cardiology Reports·Ara M Maranian, Steven R Steinhubl
May 1, 1995·Bioorganic & Medicinal Chemistry·J A ZablockiR J Lindmark
May 1, 1992·Trends in Cardiovascular Medicine·I M LubinM S Runge
Apr 23, 2003·Journal of the American College of Cardiology·Neal S Kleiman
Apr 9, 1992·The New England Journal of Medicine·E W Salzman
Mar 11, 2005·The New England Journal of Medicine·Marc S SabatineUNKNOWN CLARITY-TIMI 28 Investigators
Aug 10, 2004·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Marcello Di ValentinoAugusto Gallino
Sep 28, 2010·Journal of Neurosurgery·Muhammad Zeeshan MemonElad I Levy
Apr 1, 1992·Cardiovascular Drugs and Therapy·M Verstraete
Jan 22, 2002·Journal of the American College of Surgeons·Richard Shlansky-Goldberg
Jun 16, 2015·Journal of Thrombosis and Haemostasis : JTH·S AbsarF Ahsan
Sep 22, 2012·Annals of the New York Academy of Sciences·Reza Bavarsad Shahripour, Andrei V Alexandrov
Jul 21, 2004·Journal of the American College of Cardiology·Shinya GotoHideyuki Ishida
Mar 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·J StronyB Adelman
Oct 15, 2005·Stroke; a Journal of Cerebral Circulation·Kyung-Hee ChoDong-Wha Kang
Oct 21, 2017·Chinese Medical Journal·Lin LiMao-Ting Yuan
Dec 4, 1992·Annals of the New York Academy of Sciences·E Falk
Dec 1, 2005·Expert Review of Pharmacoeconomics & Outcomes Research·Sean M Donahoe, Marc S Sabatine
Nov 19, 2019·International Journal of Biological Macromolecules·Kashika AroraGirish Sahni
Sep 1, 1991·Progress in Cardiovascular Diseases·D CollenH K Gold

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.