Jan 1, 1977

Lysis of red blood cells in some haemolytic anaemias--the lytic effect of agkistrodon piscivorus venom in vitro

Folia haematologica : internationales Magazin für klinische und morphologische Blutforschung
V Brabec, F Kornalík

Abstract

The lysis of red blood cells induced by the Agkistrodon piscivorus venom (APV) in vitro in the presence and/or in the absence of plasma was examined in autoimmune haemolytic anaemia (AIHA), hereditary spherocytosis (HS) and paroxysmal nocturnal haemoglobinuria (PNH). Virtually haemolysis did not differ from that of normals in AIHA, it was slightly increased in HS and significantly higher in PNH, however, only in the presence of autologous or normal homologous plasma. The mechanism of PNH blood cells lysis which is probably related to the activation of the third complement component is discussed.

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Mentioned in this Paper

Pathologic Cytolysis
CFI
Complement C3 precursor
Red blood cells, blood product
Autoimmune Hemolytic Anemia
Hemolytic Complement
Paroxysmal Nocturnal Hemoglobinuria
Red Blood Cell Count Measurement
Hereditary Spherocytosis
Venoms

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Autoimmune Hemolytic Anemia

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