PMID: 8581371Oct 1, 1995Paper

Lysis of small cell carcinoma of the lung (SCCL) cells by cytokine-activated monocytes and natural killer cells in the presence of bispecific immunoconjugates containing a gastrin-releasing peptide (GRP) analog or a GRP antagonist

Journal of Hematotherapy
J ChenEdward D Ball

Abstract

Lung cancer remains the leading cause of cancer deaths in the United States. We have developed a new immunotherapeutic approach to the treatment of small cell carcinoma of the lung (SCCL) by targeting the gastrin-releasing peptide receptor (GRP-R) expressed on the surface of these cells. Bispecific immunoconjugates were constructed by chemical fusion of a GRP analog or a GRP antagonist with monoclonal antibodies directed to the cytotoxic trigger molecules Fc gamma RI and Fc gamma RIII on various immune effector cells. We demonstrated that these bispecific immunoconjugates bound to target SCCL cells in a dose-dependent manner. In the presence of these immunoconjugates, more than 80% of SCCL cells were lysed by cytokine-activated monocytes and natural killer (NK) cells measured by a 51Cr-release assay. These data indicate that bifunctional antibodies targeting GRP may have clinical use.

References

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Jul 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R O Dillman
Jan 1, 1993·Life Sciences·T W Moody, F Cuttitta

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Citations

Jan 1, 1997·International Reviews of Immunology·H RouardJ L Teillaud
Nov 4, 2000·Expert Opinion on Investigational Drugs·F P Worden, G P Kalemkerian
Jul 5, 2005·Expert Opinion on Investigational Drugs·D L DrakemanP K Wallace
May 16, 2015·Peptides·Irene Ramos-ÁlvarezRobert T Jensen
Feb 24, 2006·Biochimica Et Biophysica Acta·Oneel PatelGraham S Baldwin
Jul 2, 2015·Histochemistry and Cell Biology·Dong-Joon LeeHan-Sung Jung
Jun 4, 1998·International Journal of Cancer. Journal International Du Cancer·E J RoyD M Kranz
Oct 1, 1996·Journal of Hematotherapy·A DwengerR Mertelsmann
Oct 30, 2004·Anti-cancer Drugs·Jiehua ZhouEdward D Ball

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