Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.

Molecular Pain
Lin MaHiroshi Ueda

Abstract

We previously reported that intrathecal injection of lysophosphatidylcholine (LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 receptor, possibly via conversion to LPA by autotaxin (ATX). We examined in vivo LPA-induced LPA production using a biological titration assay with B103 cells expressing LPA1 receptors. Intrathecal administration of LPC caused time-related production of LPA in the spinal dorsal horn and dorsal roots, but not in the dorsal root ganglion, spinal nerve or sciatic nerve. LPC-induced LPA production was markedly diminished in ATX heterozygotes, and was abolished in mice that were deficient in LPA3, but not LPA1 or LPA2 receptors. Similar time-related and LPA3 receptor-mediated production of LPA was observed following intrathecal administration of LPA. In an in vitro study using spinal cord slices, LPA-induced LPA production was also mediated by ATX and the LPA3 receptor. Intrathecal administration of LPA, in contrast, induced neuropathic pain, which was abolished in mice deficient in LPA1 or LPA3 receptors. These findings suggest that feed-forward LPA production is involved in LPA-induced neuropathic pain.

References

Oct 1, 1995·Journal of Neurocytology·N D Jeffery, W F Blakemore
Dec 1, 1995·Journal of Internal Medicine·T Yokota, G K Hansson
May 12, 1998·The American Journal of Physiology·K LiliomM A Watsky
May 20, 2000·Annals of the New York Academy of Sciences·X FangG B Mills
Aug 18, 2000·Free Radical Biology & Medicine·G M Chisolm, Y Chai
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·J J ContosJ Chun
May 8, 2001·The Journal of Biological Chemistry·T MöllerB R Ransom
Sep 25, 2002·Clinical Biochemistry·Tatsuya KishimotoKoji Mizuno
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Md Harunor RashidHiroshi Ueda
Jun 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tatsuya KishimotoKoji Mizuno
Jun 15, 2004·Nature Medicine·Makoto InoueHiroshi Ueda
Jun 24, 2004·Cellular Signalling·Yuhuan Xie, Kathryn E Meier
Jul 24, 2004·Seminars in Cell & Developmental Biology·Junken Aoki
Mar 17, 2005·The Journal of Biological Chemistry·Laurens A van MeeterenWouter H Moolenaar
Feb 16, 2006·Journal of Vascular Surgery·Panagiotis KougiasChangyi Chen
Jul 11, 2006·The Journal of Biological Chemistry·Masayuki TanakaHiroyuki Arai
Oct 24, 2006·Neurochemistry International·Ryousuke FujitaHiroshi Ueda
Nov 3, 2006·Biochimica Et Biophysica Acta·Dagmar Meyer zu Heringdorf, Karl H Jakobs
Apr 27, 2007·Progress in Lipid Research·Laurens A van Meeteren, Wouter H Moolenaar
Sep 22, 2007·Journal of Leukocyte Biology·P J OjalaJ Parkkinen
Jan 17, 2008·The Journal of Biological Chemistry·Tânia Cristina Sampaio SpohrJerold Chun
Jan 29, 2008·Current Medicinal Chemistry·Takayuki MatsumotoKatsuo Kamata
Jul 16, 2008·Biochimica Et Biophysica Acta·Junken AokiShinichi Okudaira

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Citations

Aug 21, 2013·Cellular and Molecular Neurobiology·Ryo YanoHiroshi Ueda
Apr 22, 2014·Trends in Pharmacological Sciences·Julia K ArchboldMatthew J Sweet
Sep 15, 2014·Biochimica Et Biophysica Acta·Ronald P J Oude ElferinkUlrich H Beuers
Sep 11, 2012·Biochimica Et Biophysica Acta·Hiroshi UedaJun Nagai
Aug 21, 2012·Biochimica Et Biophysica Acta·Keisuke YanagidaSatoshi Ishii
Aug 14, 2012·Biochimica Et Biophysica Acta·Ji Woong Choi, Jerold Chun
Feb 1, 2011·Biochimica Et Biophysica Acta·Emi NozakiKimiko Murakami-Murofushi
Aug 26, 2010·British Journal of Pharmacology·Gabor Tigyi
Sep 17, 2013·British Journal of Pharmacology·Yosuke MatsushitaHiroshi Ueda
Mar 8, 2014·British Journal of Pharmacology·Yasuyuki KiharaJerold Chun
Apr 10, 2016·Neuropharmacology·María VelascoGraham K Sheridan
Feb 24, 2015·Progress in Lipid Research·Sabin Llona-MinguezThomas Helleday
Mar 20, 2014·Journal of Lipid Research·Yun C YungJerold Chun
Jun 28, 2018·Journal of Neurophysiology·Ileana Hernández-AraizaTamara Rosenbaum
Dec 30, 2017·International Journal of Molecular Medicine·Yuzhou LiuXin Zhao
Jun 14, 2019·Frontiers in Molecular Neuroscience·Carolina RozaJavier Márquez
Jun 28, 2019·Frontiers in Molecular Neuroscience·Sara TabbaiCarmen Pedraza
Apr 25, 2020·Journal of Neuroinflammation·Ioanna PlastiraWolfgang Sattler
Nov 7, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiroshi Ueda
Sep 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Richard R RiveraJerold Chun
Dec 2, 2020·Progress in Lipid Research·Hiroshi Ueda
Dec 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ho-Sung LeeDae-Yeon Lee
Jun 15, 2021·European Journal of Medicinal Chemistry·Bhagyalalitha MeduriBijo Mathew
Dec 4, 2019·Journal of Medicinal Chemistry·Inés González-GilSilvia Ortega-Gutiérrez

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Methods Mentioned

BETA
column chromatography
PCR
electrophoresis

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