Lysophosphatidic acid, human osteoblast formation, maturation and the role of 1α,25-Dihydroxyvitamin D3 (calcitriol)

Biochimica Et Biophysica Acta
Jason Peter Mansell, Julia Blackburn

Abstract

The simplest signalling lipid Lysophosphatidic acid (LPA) elicits pleiotropic actions upon most mammalian cell types. Although LPA has an established role in many biological processes, particularly wound healing and cancer, the function of LPA for human osteoblast (hOB) biology is still unravelling. Early studies, identified in this review, gave a reliable indication that LPA, via binding to one of several transmembrane receptors, stimulated multiple intracellular signalling networks coupled to changes in cell growth, fibronectin binding, maturation and survival. The majority of studies exploring the actions of LPA on hOB responses have done so using the lipid in isolation. Our own research has focussed on the co-operation of LPA with the active vitamin D3 metabolite, 1α25,dihydroxycholecalciferol (calcitriol), in light of a serendipitous discovery that calcitriol, in a serum-free culture setting, was unable to promote hOB maturation. We subsequently learnt that the serum-borne factor co-operating with calcitriol to enhance hOB differentiation was LPA bound to the albumin fraction of whole serum. Recent studies from our laboratory have identified that LPA and calcitriol are a potent pairing for securing hOB formation from their...Continue Reading

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Citations

Dec 7, 2013·PloS One·Bernard Y K BinderJ Kent Leach
Jul 8, 2015·The Journal of Endocrinology·Ichiro KanekoPeter W Jurutka
Feb 4, 2015·Journal of Lipid Research·Mohamad NavabAlan M Fogelman
Feb 18, 2020·The Journal of Clinical Investigation·Petra SimicEugene P Rhee
Apr 27, 2021·Current Opinion in Nephrology and Hypertension·Petra SimicEugene P Rhee

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