Abstract
Lysophosphatidic acid (LPA) is a lipid growth factor known to regulate diverse cell functions, including cell proliferation, survival, and apoptosis. Tight regulation of cell survival in neuronal precursor is essential during neurogenesis in both developing and adult brain. Increasing data show that diverse external factors including LPA play roles in controlling cell survival and apoptosis in early developing neurons. However, the underlying control mechanism remains unclear. To explore how LPA regulates cell survival or apoptosis in a developing neuron, mechanisms for cell survival and signaling cascades by LPA were investigated in H19-7 hippocampal progenitor cells. Here, we showed that LPA promotes cell survival by protection from apoptosis. Mcl-1 was demonstrated to be crucial in LPA-induced cell survival by transfection of the siRNA specific for Mcl-1 and overexpression of Mcl-1. LPA-induced cell survival was critically mediated by the upregulation of Mcl-1 which was regulated not only through a post-translational control but a transcriptional control. Mcl-1 stabilization by LPA-induced inhibitory phosphorylation of GSK-3 contributed predominantly to the Mcl-1 upregulation. Both LPA-induced cell survival and the GSK-3 pho...Continue Reading
References
Jul 11, 1998·The Journal of Comparative Neurology·M van Lookeren Campagne, R Gill
Dec 29, 2000·Cellular and Molecular Life Sciences : CMLS·C AkgulS W Edwards
Mar 8, 2003·Neuro-Signals·Stephen K-F Wong
Mar 17, 2004·The Journal of Biological Chemistry·Brigitte Anliker, Jerold Chun
Mar 27, 2004·Science·Xianhua PiaoChristopher A Walsh
Apr 13, 2004·Nature Cell Biology·J I-Ju LeuDonna L George
Feb 19, 2005·Science·Joseph T OpfermanStanley J Korsmeyer
Feb 3, 2006·Molecular Biology of the Cell·C Laura SayasWouter H Moolenaar
Mar 4, 2006·Cell Death and Differentiation·R S AkhtarK A Roth
Mar 18, 2006·Neuroreport·Hae Jin RheeSung-Oh Huh
Mar 3, 2007·Journal of Proteome Research·Martin H MaurerWolfgang Kuschinsky
May 29, 2007·Cellular and Molecular Life Sciences : CMLS·J E Forde, T C Dale
May 3, 2008·Science·Tina M ThorntonMercedes Rincon
Citations
Sep 13, 2012·Molecular Pharmacology·Gyöngyi N KissGabor Tigyi
Oct 18, 2013·Tissue Engineering. Part a·Bernard Y K BinderJ Kent Leach
Mar 7, 2013·Journal of Lipid Research·Frisca FriscaAlice Pébay
Sep 8, 2012·Biochimica Et Biophysica Acta·David N BrindleyGabor J Tigyi
Apr 24, 2012·Annals of Vascular Surgery·Jose M GarridoIndalecio Sánchez-Montesinos
Aug 11, 2015·Molecules and Cells·Hyeon-Joong KimSeung-Yeol Nah
Jun 3, 2015·Tissue Engineering. Part B, Reviews·Bernard Y K BinderJ Kent Leach
Feb 24, 2015·Progress in Lipid Research·Efrosini BarbayianniGeorge Kokotos
Aug 18, 2017·Journal of Neurochemistry·Maria C OlianasPierluigi Onali
Mar 7, 2019·Apoptosis : an International Journal on Programmed Cell Death·Maria C OlianasPierluigi Onali
Aug 1, 2014·Molecules and Cells·Nam-Ho KimSung-Oh Huh
Aug 3, 2017·Apoptosis : an International Journal on Programmed Cell Death·Narengerile LiAlatangaole Damirin
Oct 23, 2013·Molecular Medicine Reports·Yuanjie SunHae Jin Rhee
May 7, 2015·Acta Crystallographica. Section D, Biological Crystallography·Sun Hye ChoiLin Woo Kang
Sep 25, 2019·Molecular Cancer Therapeutics·Xiaoyun TangDavid N Brindley