Lysophosphatidic acid induces upregulation of Mcl-1 and protects apoptosis in a PTX-dependent manner in H19-7 cells

Cellular Signalling
Yuanjie SunSung-Oh Huh

Abstract

Lysophosphatidic acid (LPA) is a lipid growth factor known to regulate diverse cell functions, including cell proliferation, survival, and apoptosis. Tight regulation of cell survival in neuronal precursor is essential during neurogenesis in both developing and adult brain. Increasing data show that diverse external factors including LPA play roles in controlling cell survival and apoptosis in early developing neurons. However, the underlying control mechanism remains unclear. To explore how LPA regulates cell survival or apoptosis in a developing neuron, mechanisms for cell survival and signaling cascades by LPA were investigated in H19-7 hippocampal progenitor cells. Here, we showed that LPA promotes cell survival by protection from apoptosis. Mcl-1 was demonstrated to be crucial in LPA-induced cell survival by transfection of the siRNA specific for Mcl-1 and overexpression of Mcl-1. LPA-induced cell survival was critically mediated by the upregulation of Mcl-1 which was regulated not only through a post-translational control but a transcriptional control. Mcl-1 stabilization by LPA-induced inhibitory phosphorylation of GSK-3 contributed predominantly to the Mcl-1 upregulation. Both LPA-induced cell survival and the GSK-3 pho...Continue Reading

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Citations

Sep 8, 2012·Biochimica Et Biophysica Acta·David N BrindleyGabor J Tigyi
Feb 24, 2015·Progress in Lipid Research·Efrosini BarbayianniGeorge Kokotos
Mar 7, 2019·Apoptosis : an International Journal on Programmed Cell Death·Maria C OlianasPierluigi Onali
Aug 3, 2017·Apoptosis : an International Journal on Programmed Cell Death·Narengerile LiAlatangaole Damirin
May 7, 2015·Acta Crystallographica. Section D, Biological Crystallography·Sun Hye ChoiLin Woo Kang

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