Lysophosphatidic acid receptor-dependent secondary effects via astrocytes promote neuronal differentiation

The Journal of Biological Chemistry
Tânia Cristina Sampaio SpohrJerold Chun

Abstract

Lysophosphatidic acid (LPA) is a simple phospholipid derived from cell membranes that has extracellular signaling properties mediated by at least five G protein-coupled receptors referred to as LPA(1)-LPA(5). In the nervous system, receptor-mediated LPA signaling has been demonstrated to influence a range of cellular processes; however, an unaddressed aspect of LPA signaling is its potential to produce specific secondary effects, whereby LPA receptor-expressing cells exposed to, or "primed," by LPA may then act on other cells via distinct, yet LPA-initiated, mechanisms. In the present study, we examined cerebral cortical astrocytes as possible indirect mediators of the effects of LPA on developing cortical neurons. Cultured astrocytes express at least four LPA receptor subtypes, known as LPA(1)-LPA(4). Cerebral cortical astrocytes primed by LPA exposure were found to increase neuronal differentiation of cortical progenitor cells. Treatment of unprimed astrocyte-progenitor cocultures with conditioned medium derived from LPA-primed astrocytes yielded similar results, suggesting the involvement of an astrocyte-derived soluble factor induced by LPA. At least two LPA receptor subtypes are involved in LPA priming, since the priming e...Continue Reading

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Citations

May 25, 2010·Cell and Tissue Research·Yona GoldshmitAnn M Turnley
Jan 12, 2010·Clinical Neuropharmacology·Jerold Chun, Hans-Peter Hartung
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Ji Woong ChoiJerold Chun
Mar 10, 2010·Neurochemical Research·Jader NonesFlávia Carvalho Alcantara Gomes
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May 17, 2012·Journal of Neuroscience Research·Tânia Cristina Leite de Sampaio E SpohrStevens Kastrup Rehen
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