PMID: 9429765Jan 16, 1998Paper

Lysophosphatidic acid sensitises Ca2+ influx through mechanosensitive ion channels in cultured lens epithelial cells

Cellular Signalling
H OhataK Momose

Abstract

We investigated the effect of lysophosphatidic acid (LPA), a bioactive phospholipid, on the response in cytosolic free Ca2+ concentration ([Ca2+]i) to mechanical stress in cultured bovine lens epithelial cells. Spritzing of bath solution onto cells as mechanical stress caused marked increase in [Ca2+]i in the presence of LPA and this increase was concentration-dependent (1-10 microM), whereas neither addition of LPA alone nor the mechanical stress in the absence of LPA affected [Ca2+]i. The mechanical stress-induced increase in [Ca2+]i in the presence of LPA was inhibited by removing extracellular Ca2+ or by addition of Gd3+, a blocker of mechanosensitive cation channels, but not by nicardipine, thapsigargin, an inhibitor of endoplasmic reticulum-ATPase pump, or U73122, a phospholipase C inhibitor. These results show that LPA sensitises Ca2+ influx through cation-selective mechanosensitive channels, but does not sensitise Ca2+ release from intracellular stores, triggered by changes in mechanical stress. On the other hand, phosphatidic acid had less of a sensitising effect than LPA, and neither lysophosphatidylcholine nor chlorpromazine had any effect. Also Ca2+ mobilising agonists, ATP, histamine and carbachol, did not sensitis...Continue Reading

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Citations

Jan 31, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Robert E KraichelyGianrico Farrugia
Oct 27, 2004·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Hisayuki OhataKazutaka Momose
Dec 9, 2008·Experimental Eye Research·Jeremy D Rhodes, Julie Sanderson
Apr 10, 2016·Neuropharmacology·María VelascoGraham K Sheridan
Mar 12, 2021·Journal of Physiology and Biochemistry·Julliana F Sant'AnnaMarcelo Einicker-Lamas

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