Lysophosphatidylcholine is involved in the antigenicity of oxidized LDL

Arteriosclerosis, Thrombosis, and Vascular Biology
R WuJ Frostegård

Abstract

Lysophosphatidylcholine (LPC) is formed by hydrolysis of PC in low density lipoprotein (LDL) and cell membranes by phospholipase A2 or by oxidation. Oxidized (ox) LDL activates endothelial cells, an effect mimicked by LPC. oxLDL also has the capacity to activate T and B cells, and antibody titers to oxLDL are related to the degree of atherosclerosis. The antigen in oxLDL responsible for its immune-stimulatory capacity is not well characterized, and we hypothesized that LPC was involved. We demonstrate herein the presence of antibodies against LPC, both of the IgG and IgM isotype, in 210 healthy individuals. This antibody reactivity was not specifically related to oxidation of the fatty acid moiety in LPC, since LPC containing only palmitic acid showed antibody titers equivalent to those of LPC containing unsaturated fatty acids. Antibody titers to PC were low compared with LPC, and hydrolysis of PC at the sn-2 position is thus essential for immune reactivity. There was a close correlation between anti-oxLDL and anti-LPC antibodies. Furthermore, LPC competitively inhibited anti-oxLDL reactivity, which indicates that LPC may explain a significant part of the immune-stimulatory properties of oxLDL. LPC, being a lipid, is not likel...Continue Reading

References

Apr 1, 1976·Biochemical Medicine·K Yagi
May 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M E RosenfeldJ L Witztum
Oct 1, 1990·Current Opinion in Rheumatology·D D Gladman
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W PalinskiJ L Witztum
Apr 6, 1989·The New England Journal of Medicine·D SteinbergJ L Witztum
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M T QuinnD Steinberg
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·S StemmeG K Hansson
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Liu, P V Subbaiah
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·T NakanoR Ross
Aug 1, 1993·The Journal of Clinical Investigation·H F McMurrayD Steinberg
Jan 1, 1996·Annual Review of Medicine·S S Shapiro
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON

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Citations

Sep 12, 2003·Current Rheumatology Reports·José Delgado Alves, Bruno Grima
Jul 16, 2003·Atherosclerosis·Guo-Zhong FeiJohan Frostegård
Sep 15, 2001·Free Radical Biology & Medicine·O NärvänenS Ylä-Herttuala
Nov 30, 2000·Trends in Cardiovascular Medicine·P Sartipy, E Hurt-Camejo
Jul 9, 1999·Biochimica Et Biophysica Acta·A Wang, E A Dennis
Jul 20, 2002·Trends in Molecular Medicine·Fulvio UrsiniAlex Sevanian
Aug 30, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Harmen H M DraismaDorret I Boomsma
Apr 28, 2000·Annals of the Rheumatic Diseases·S Manzi, M C Wasko
Dec 8, 2006·Arthritis Research & Therapy·Cristiano AlessandriGuido Valesini
Mar 19, 2011·Vascular Health and Risk Management·Samuel O Olusi, Sunila George
Apr 11, 2017·Nature Reviews. Nephrology·Anton Gisterå, Göran K Hansson
May 25, 2005·Journal of Internal Medicine·J Frostegård
Jan 4, 2017·Trends in Cardiovascular Medicine·Sumeyya AkyolChu-Huang Chen
Apr 17, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Hans GrönlundJohan Frostegård
Sep 24, 2004·The Journal of Membrane Biology·H A Wilson-AshworthJ D Bell
Jul 9, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dolly Mehta
Aug 30, 2005·Annals of the New York Academy of Sciences·Guido Valesini, Cristiano Alessandri
Sep 11, 2020·ESC Heart Failure·Charlotte AnderssonRamachandran S Vasan
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Chaofu KeYueping Shen
Mar 11, 2009·Biochimica Et Biophysica Acta·Constantinos C Tellis, Alexandros D Tselepis
May 12, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Maria F Lopes-Virella, Gabriel Virella
May 7, 2011·Autoimmunity Reviews·Cristiano AlessandriGuido Valesini

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