Lysophosphatidylcholine Promotes Phagosome Maturation and Regulates Inflammatory Mediator Production Through the Protein Kinase A-Phosphatidylinositol 3 Kinase-p38 Mitogen-Activated Protein Kinase Signaling Pathway During Mycobacterium tuberculosis Infection in Mouse Macrophages

Frontiers in Immunology
Hyo-Ji LeeYu-Jin Jung

Abstract

Tuberculosis is caused by the infectious agent Mycobacterium tuberculosis (Mtb). Mtb has various survival strategies, including blockade of phagosome maturation and inhibition of antigen presentation. Lysophosphatidylcholine (LPC) is a major phospholipid component of oxidized low-density lipoprotein and is involved in various cellular responses, such as activation of second messengers and bactericidal activity in neutrophils. In this study, macrophages were infected with a low infectious dose of Mtb and treated with LPC to investigate the bactericidal activity of LPC against Mtb. In macrophages infected with Mtb strain, H37Ra or H37Rv, LPC suppressed bacterial growth; however, this effect was suppressed in bone marrow-derived macrophages (BMDMs) isolated from G2A (a G protein-coupled receptor involved in some LPC actions) knockout mice. LPC also promoted phagosome maturation via phosphatidylinositol 3 kinase (PI3K)-p38 mitogen-activated protein kinase (MAPK)-mediated reactive oxygen species production and intracellular Ca2+ release during Mtb infection. In addition, LPC induced increased levels of intracellular cyclic adenosine monophosphate (cAMP) and phosphorylated glycogen synthase kinase 3 beta (GSK3β) in Mtb-infected macro...Continue Reading

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Citations

Apr 9, 2020·Experimental and Therapeutic Medicine·Lei QianGuangliang Liu
May 20, 2020·Infection and Immunity·Kerstin PohlKenneth C Malcolm
Dec 5, 2019·Frontiers in Immunology·Andrea Kristina HorstLinda Diehl
Jan 1, 2021·Frontiers in Oncology·Jane KooAlisa B Lee-Sherick
Feb 23, 2020·Life Sciences·Panpan LiuCong Peng
Jun 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Luciana P TavaresLirlândia P Sousa
Jan 22, 2021·The Journal of Veterinary Medical Science·Son Hai VuHyun-Jin Kim
May 22, 2021·Frontiers in Immunology·Ricarda Cortés-VieyraVíctor M Baizabal-Aguirre
Jun 26, 2021·Pharmacology & Therapeutics·Jody Tori O Cabrera, Ayako Makino
Aug 6, 2021·Molecular Biology Reports·Sadhana Sundararajan, Rajiniraja Muniyan

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Methods Mentioned

BETA
Enzyme-linked immunosorbent assay
confocal microscopy
ELISA
GTPases

Software Mentioned

GraphPad
GraphPad Prism

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