Lysophosphatidylserine induces eosinophil extracellular trap formation and degranulation: Implications in severe asthma.

Allergy
Hye Jeong KimI Y Chung

Abstract

Recent evidence demonstrates that activated eosinophils undergo a distinct form of lytic cell death, accompanied by formation of DNA-based eosinophil extracellular trap (EET) and degranulation, enhancing inflammatory immune responses in asthmatic airways. We previously showed that human blood eosinophils undergo degranulation in response to lysophosphatidylserine (LysoPS), an inflammatory lipid mediator, and strongly express P2Y10, a LysoPS receptor. We evaluated EET, degranulation, and cell death of eosinophils in response to various concentrations of LysoPS. We also compared responsiveness to LysoPS between eosinophils from severe and nonsevere asthmatics. Extensive EET formation was elicited from a substantial fraction of stimulated eosinophils in response to 50 μmol/L LysoPS. Analyses for LDH and eosinophil-derived neurotoxin release showed that both lytic cell death and degranulation accompanied EET formation in response to LysoPS. Cytological analyses demonstrated that citrullinated histone 3 was present in the extracellular, filamentous DNA structure embedded with eosinophil granules. The LysoPS-induced EET was independent of ROS production and irrelevant to several signaling pathways examined, but dependent on protein a...Continue Reading

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Citations

Oct 12, 2020·Allergy·Koichiro AsanoMasami Taniguchi
Mar 9, 2021·Frontiers in Microbiology·Marina Valente BarrosoJosiane S Neves
Mar 9, 2021·Frontiers in Microbiology·Juliana da Costa SilvaRodrigo Tinoco Figueiredo
Jun 16, 2021·Cell Biochemistry and Biophysics·Jumpei OmiJunken Aoki

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