Lysosomal acid lipase activity and liver fibrosis in the clinical continuum of non-alcoholic fatty liver disease

Liver International : Official Journal of the International Association for the Study of the Liver
Francesco BarattaMaria Del Ben

Abstract

Recent evidence showed a reduced activity of the lysosomal acid lipase (LAL) in patients with non-alcoholic fatty liver disease (NAFLD) and cryptogenic cirrhosis (CC). However, the relationship between LAL activity and liver fibrosis has never been investigated. Cross-sectional study including 575 outpatients referred for the management of cardio-metabolic and liver disease. The absence of liver fibrosis was defined by a FIB-4 < 1.30 and NAFLD fibrosis score (NFS) <-1.455. LAL activity was measured with dried blood spot technique. Overall, 515 patients had a diagnosis of NAFLD (454 NAFL and 61 biopsy-proven NASH) and 60 of CC. The value of LAL activity progressively decreased from healthy subjects to NAFL/NASH patients to CC (P < .001). LAL activity was reduced by 10% in patients with NAFL, by 20% in NASH and by 50% in CC. The prevalence of CC decreased across the tertiles of LAL activity: 22.2% in the lowest, 4.6% in the intermediate and 0.5% in the highest tertile. In NAFLD patients, 69.9% had a FIB4 < 1.30, and 43.1% a NFS <-1.455. Multivariate logistic regression analysis showed that Log (LAL activity) was associated with FIB-4 < 1.30 (Odds ratio [OR] 2.19 95% confidence interval [CI] 1.33-3.62, P = .002) and NFS < -1.455 (...Continue Reading

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Citations

Aug 20, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Simone CarottiUmberto Vespasiani-Gentilucci
Nov 26, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Jiang DuJuntang Lin
May 21, 2020·World Journal of Clinical Cases·Elias Badal RashuLise L Gluud
Mar 5, 2021·Clinics and Research in Hepatology and Gastroenterology·Rutiane Ullmann ThoenMário Reis Álvares-da-Silva
Aug 21, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Feifei LiHong Yu

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