Lysosomal Cathepsin Protease Gene Expression Profiles in the Human Brain During Normal Development

Journal of Molecular Neuroscience : MN
Amy HsuVivian Hook

Abstract

Cathepsin protease genes are necessary for protein homeostasis in normal brain development and function. The diversity of the 15 cathepsin protease activities raises the question of what are the human brain expression profiles of the cathepsin genes during development from prenatal and infancy to childhood, adolescence, and young adult stages. This study, therefore, evaluated the cathepsin gene expression profiles in 16 human brain regions during development by quantitative RNA-sequencing data obtained from the Allen Brain Atlas resource. Total expression of all cathepsin genes was the lowest at the early prenatal stage which became increased at the infancy stage. During infancy to young adult phases, total gene expression was similar. Interestingly, the rank ordering of gene expression among the cathepsins was similar throughout the brain at the age periods examined, showing (a) high expression of cathepsins B, D, and F; (b) moderate expression of cathepsins A, L, and Z; (c) low expression of cathepsins C, H, K, O, S, and V; and (d) very low expression of cathepsins E, G, and W. Results show that the human brain utilizes well-defined, balanced patterns of cathepsin gene expression throughout the different stages of human brain...Continue Reading

References

Apr 5, 2003·Acta Neuropathologica·Hitoshi KikuchiJun-ichi Kira
Jul 29, 2005·Nature Reviews. Neuroscience·Mylvaganam JeyakumarFrances M Platt
Jan 21, 2006·Neurobiology of Disease·Yun J KimMarian DiFiglia
Nov 21, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Hans-Gert BernsteinUwe Lendeckel
Feb 5, 2009·Bioinformatics·João Pedro de MagalhãesGeorge M Church
Oct 6, 2010·The Journal of Clinical Investigation·Jochen ReiserThomas Reinheckel
Mar 7, 2012·The Journal of Biological Chemistry·Lydiane FunkelsteinVivian Hook
Sep 22, 2012·Nature·Michael J HawrylyczAllan R Jones
Jan 9, 2013·Human Molecular Genetics·Katherine R SmithMelanie Bahlo
Aug 8, 2013·Nature Medicine·Ralph A Nixon
Nov 16, 2013·Molecular Neurobiology·Anja Pišlar, Janko Kos
Jul 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ryan P McGlinchey, Jennifer C Lee
Oct 21, 2015·Journal of the American Society for Mass Spectrometry·Vivian Hook, Nuno Bandeira
Mar 1, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Tim MoorsWilma D J van de Berg
Apr 14, 2016·Journal of Neurology·Stefano DocciniAlessandro Simonati
Apr 30, 2016·Ageing Research Reviews·Veronika StokaBoris Turk
Jun 17, 2016·Ageing Research Reviews·Tetsumori Yamashima
Aug 16, 2016·Gastroenterology·Rupjyoti TalukdarAshok K Saluja
Aug 25, 2017·Molecular Neurodegeneration·Xiaolai ZhouFenghua Hu

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Citations

Apr 20, 2020·Biochimica Et Biophysica Acta. Proteins and Proteomics·Vivian HookGregory Hook
Nov 24, 2020·Biochimica Et Biophysica Acta. Proteins and Proteomics·Iztok DolencVeronika Stoka
Feb 5, 2022·Biochemistry·Michael C YoonVivian Hook

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Methods Mentioned

BETA
RNA-Seq

Software Mentioned

GraphPad Prism

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