Abstract
Eleven lysosomal enzyme activities were tested in lymphocytes from normal individuals and patients with chronic lymphocytic leukemia. The activities of all enzymes, except acid phosphatase, were significantly lower in the leukemic lymphocytes (p less than 0.001). In addition the activities were tested in purified T- and non-T lymphocytes and in monocytes. For most enzymes the activities are similar in the three cell types, except for alpha-D-galactosidase, arylsulphatase B and alpha-D-glucosidase, which are lower in T lymphocytes, and N-acetyl-beta-D-glucosaminidase which is lower in non-T cells. In T and B lymphoblastic cell lines the activities are within the range for leukemic lymphocytes. No differences were found between the T and the B cell lines.
References
Apr 1, 1976·The Journal of Experimental Medicine·E BeutlerG Pangalis
Dec 1, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·J TroostG E Staal
Apr 2, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·A D CrockardJ M Bridges
Jan 1, 1975·Clinical Immunology and Immunopathology·M A PellegrinoR A Reisfeld
Aug 1, 1979·FEBS Letters·T Tanaka
Oct 16, 1980·The New England Journal of Medicine·J BlattD G Poplack
Aug 1, 1980·Biochemical Society Transactions·A D CrockardM H Lewis
Sep 1, 1980·Scandinavian Journal of Haematology·A D Crockard, T C Morris
Sep 1, 1980·Biochimica Et Biophysica Acta·R J KraaijenhagenG E Staal
Citations
Feb 14, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·A LombardoG Tettamanti
Jan 1, 1983·The International Journal of Biochemistry·G LundbladA Måhlén
Jan 1, 1985·The International Journal of Biochemistry·H Chelibonova-LorerM Antonova
Jun 1, 1996·The International Journal of Biochemistry & Cell Biology·E Gil-MartínA Fernández-Briera
Aug 11, 2004·Clinical Biochemistry·Hikmet KoçakPernur Oner
Feb 1, 1997·Clinical Biochemistry·E Gil-MartínA Fernández-Briera
Sep 1, 1983·Journal of Clinical Pathology·G T BesleyA E Dewar
Jan 1, 1989·Critical Reviews in Oncology/hematology·J A Alhadeff
Jul 14, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yildiz Oner-IyidoğanZeynep Ozbek-Kir
Sep 1, 1987·Australian Veterinary Journal·P J HealyK G Reichmann
Aug 1, 1986·European Journal of Biochemistry·J Sainte-MarieA Bienvenue
Jan 1, 1992·The Psychiatric Quarterly·C D Clements
Mar 1, 1991·Biulleten' eksperimental'noĭ biologii i meditsiny·A L VlasovaN D Khoroshko
Mar 1, 1985·Scandinavian Journal of Haematology·A D CrockardJ M Bridges