Lysosomal proteins in cell death and autophagy

The FEBS Journal
Michaela Mrschtik, Kevin M Ryan

Abstract

Nearly 60 years ago, lysosomes were first described in the laboratory of Christian de Duve, a discovery that significantly contributed to him being awarded a share of the 1974 Nobel Prize in Physiology or Medicine for elucidating 'the structural and functional organization of the cell'. Initially thought of as a simple waste degradation facility of the cell, these organelles recently emerged as signalling centres with connections to major cellular processes. This review provides an overview of the many roles of lysosomal proteins in two of these processes: cell death and autophagy. We discuss both resident lysosomal proteins as well those that temporarily associate with lysosomes to influence autophagy and cell death pathways. Particular focus is given to studies in mammalian cells and in vivo systems.

References

May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S OhkumaT Takano
Dec 15, 1983·European Journal of Biochemistry·C de Duve
Oct 3, 1999·The EMBO Journal·M HeinrichS Schütze
Oct 5, 2001·The Biochemical Journal·K KågedalU T Brunk
Jan 24, 2004·Cell Death and Differentiation·M HeinrichS Schütze
Aug 18, 2004·The Journal of Experimental Medicine·Jesper NylandstedMarja Jäättelä
Jan 18, 2006·Biochimica Et Biophysica Acta·Claudine TardyNathalie Andrieu-Abadie
May 16, 2006·Apoptosis : an International Journal on Programmed Cell Death·Cathrine NilssonKarin Ollinger
Feb 17, 2007·Cell Death and Differentiation·D CrightonK M Ryan
Nov 15, 2007·Autophagy·Carmine SettembreAndrea Ballabio
Feb 27, 2008·The Journal of Experimental Medicine·Sébastien ConusHans-Uwe Simon
May 13, 2008·The Journal of Biological Chemistry·Gabriela Droga-MazovecBoris Turk
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Vito TurkDusan Turk
Jan 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ho-Chou TuEmily H-Y Cheng
Jun 27, 2009·Science·Marco SardielloAndrea Ballabio
Sep 17, 2009·Biochemical Society Transactions·J Paul LuzioNicholas A Bright
Dec 26, 2009·Current Opinion in Cell Biology·Zhifen Yang, Daniel J Klionsky
Jan 16, 2010·Apoptosis : an International Journal on Programmed Cell Death·Ann-Charlotte JohanssonKarin Ollinger
Feb 23, 2010·Biochemical and Biophysical Research Communications·Shunya Sahara, Tetsumori Yamashima
Oct 20, 2010·Proteomics·Bernd A SchröderPaul Saftig
Dec 2, 2010·Biochemical Society Transactions·J Paul LuzioNicholas A Bright
Feb 22, 2011·Nature Cell Biology·Peter A KreuzalerChristine J Watson
Mar 12, 2011·Nature Cell Biology·Viktor I KorolchukDavid C Rubinsztein
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yueguang RongMichael J Lenardo
May 28, 2011·Science·Carmine SettembreAndrea Ballabio
Jul 15, 2011·Human Molecular Genetics·Michela PalmieriAndrea Ballabio
Aug 2, 2011·The EMBO Journal·Samuel Peña-LlopisJames Brugarolas

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Citations

Jan 20, 2016·Expert Reviews in Molecular Medicine·Mahmoud IranpourSaeid Ghavami
Dec 15, 2015·The FEBS Journal·Seamus J Martin
Jun 12, 2016·Archives of Biochemistry and Biophysics·Toshihiro KurahashiJunichi Fujii
Oct 13, 2016·Assay and Drug Development Technologies·Romina J PaglieroDavid A Egan
Dec 20, 2016·The Journal of Clinical Investigation·Dale W HaileyDavid W Raible
Dec 21, 2016·The FEBS Journal·Emily J Chenette
Oct 22, 2016·Apoptosis : an International Journal on Programmed Cell Death·Alfredo Lagunas-MartínezPatricio Gariglio
Dec 22, 2016·Biological Chemistry·Nežka KavčičBoris Turk
May 12, 2016·Journal of Cell Science·Teisha J RowlandMatthew R G Taylor
Apr 27, 2016·Infection and Immunity·Nobuo OkahashiShigetada Kawabata
Apr 12, 2019·Medicinal Research Reviews·Xin SunJianbin Zhang
Dec 19, 2015·Cell Death Discovery·L M LindqvistE H Baehrecke
Nov 18, 2017·Nature Reviews. Drug Discovery·Frances M Platt
Jun 20, 2019·Cell Cycle·Surinder M SoondAndrey A Zamyatnin
Jun 22, 2017·Future Medicinal Chemistry·Yan Xiang WangDan Qing Song
Mar 17, 2018·Oncotarget·Anna SzewczykJulita Kulbacka
Jun 18, 2020·International Journal of Molecular Sciences·Tamás Csizmadia, Péter Lőw
Aug 6, 2019·Biochemia Medica·Slavica DodigIvan Pavić
Apr 7, 2018·Neural Regeneration Research·Reggie H C LeeHung Wen Lin
May 15, 2019·Biology·Mats I Nilsson, Mark A Tarnopolsky
Oct 13, 2020·Frontiers in Neuroscience·Yang-Hee KimJae-Young Koh
Sep 19, 2020·The Journal of Infectious Diseases·Alon Schneider HaitTrine H Mogensen
Dec 15, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Claudia Cs ChiniEduardo N Chini
Dec 20, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Pandian NagakannanEftekhar Eftekharpour

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