Lysosomal redox-active iron is important for oxidative stress-induced DNA damage

Annals of the New York Academy of Sciences
Tino KurzUlf T Brunk

Abstract

Data show that specifically chelating lysosomal redox-active iron can prevent most H(2)O(2)-induced DNA damage. Lysosomes seem to contain the major pool of redox-active labile iron within the cell. Under oxidative stress conditions, this iron may then relocate to the nucleus and play an important role for DNA damage by taking part in Fenton reactions.

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May 17, 2003·The Journal of Pharmacology and Experimental Therapeutics·Christine BrabeckAlexander Burkle

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Citations

Feb 21, 2006·Antioxidants & Redox Signaling·Judith A Potashkin, Gloria E Meredith
Sep 12, 2008·Carcinogenesis·Kenny ChitcholtanJacqueline I Keenan
Apr 18, 2009·Biomaterials·Stefaan J H SoenenMarcel De Cuyper
Sep 15, 2007·Free Radical Biology & Medicine·Tiago L Duarte, George D D Jones
Jun 19, 2013·Free Radical Biology & Medicine·Colins O EnoChi Li
Sep 2, 2016·Magnetic Resonance Imaging·Sundararaman Swaminathan
Jan 13, 2009·Archives of Biochemistry and Biophysics·Tobias JungTilman Grune
Oct 21, 2017·Molecular Neurobiology·G MorrisB K Puri
Jan 21, 2018·Redox Biology·Agnieszka GrzelakMarcin Kruszewski
Aug 30, 2005·Inorganic Chemistry·Beth WilsonKathryn B Grant

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