Lysosphingolipid receptor-mediated diuresis and natriuresis in anaesthetized rats

British Journal of Pharmacology
A BischoffM C Michel

Abstract

Lysosphingolipids such as sphingosine-1-phosphate (SPP) and sphingosylphosphorylcholine (SPPC) can act on specific G-protein-coupled receptors. Since SPP and SPPC cause renal vasoconstriction, we have investigated their effects on urine and electrolyte excretion in anaesthetized rats. Infusion of SPP (1 - 30 microg kg(-1) min(-1)) for up to 120 min dose-dependently but transiently (peak after 15 min, disappearance after 60 min) reduced renal blood flow without altering endogenous creatinine clearance. Nevertheless, infusion of SPP increased diuresis, natriuresis and calciuresis and, to a lesser extent, kaliuresis. These tubular lysosphingolipid effects developed more slowly (maximum after 60 - 90 min) and also abated more slowly upon lysosphingolipid washout than the renovascular effects. Infusion of SPPC, sphingosine and glucopsychosine (3 - 30 microg kg(-1) min(-1) each) caused little if any alterations in renal blood flow but also increased diuresis, natriuresis and calciuresis and, to a lesser extent, kaliuresis. Pretreatment with pertussis toxin (10 microg kg(-1) 3 days before the acute experiment) abolished the renovascular and tubular effects of 30 microg kg(-1) min(-1) SPP. These findings suggest that lysosphingolipids ...Continue Reading

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Citations

Mar 8, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Claudia CzyborraMartin C Michel
Mar 30, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Denise G Hemmings
Jun 19, 2002·Biochimica Et Biophysica Acta·Dagmar Meyer zu HeringdorfKarl H Jakobs
Jan 30, 2002·British Journal of Pharmacology·Peter CzyborraAngela Bischoff
Jun 19, 2007·Biochemistry. Biokhimii︠a︡·E V Dyatlovitskaya
Apr 12, 2011·American Journal of Physiology. Renal Physiology·Qing ZhuNingjun Li
Apr 23, 2011·American Journal of Physiology. Renal Physiology·Edwin K Jackson
Jul 7, 2009·Pharmacology & Therapeutics·Andrea Huwiler, Josef Pfeilschifter
Apr 19, 2008·European Journal of Pharmacology·Astrid E Alewijnse, Stephan L M Peters
Mar 17, 2016·World Journal of Biological Chemistry·Luciana MorlaGilles Crambert
Sep 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John N LorenzA John MacLennan
Jun 28, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel A WalshStephen C Jameson
Oct 27, 2004·British Journal of Pharmacology·Astrid E AlewijnseMartin C Michel
May 19, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Klaus AktoriesThomas Wieland
Aug 8, 2019·American Journal of Physiology. Renal Physiology·Suttira Intapad
Feb 27, 2008·Biochemistry. Biokhimii︠a︡·E V Dyatlovitskaya
Dec 22, 2020·Scandinavian Journal of Medicine & Science in Sports·Katarzyna HodunMarcin Baranowski

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