Lysostaphin in experimental renal infections.

Journal of Bacteriology
E F Harrison, W A Zygmunt

Abstract

By use of a renal staphylococcal infection model in mice, single intravenous doses of lysostaphin ranging from 1.56 to 50 mg/kg were effective in: (i) controlling the staphylococcal population of kidneys, (ii) reducing the mortality rate, and (iii) clearing high numbers of kidneys of infection. Semisynthetic penicillins and other antistaphylococcal antibiotics given in the same manner did not have significant activity. Only by the administration of a long-acting, depot form of penicillin (Bicillin) could results comparable to those seen with lysostaphin be obtained. The results of this study suggest that lysostaphin may be useful in staphylococcal septicemias in preventing the establishment of new foci of infection.

References

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Citations

May 23, 2002·Antimicrobial Agents and Chemotherapy·Nandini KiriMichael W Climo
Apr 19, 2010·Pharmaceuticals·Maria do Carmo de Freire BastosMarcus Lívio Varella Coelho
Apr 17, 2001·Antimicrobial Agents and Chemotherapy·M W ClimoG L Archer
Feb 10, 2017·Molecular & Cellular Proteomics : MCP·Natalie C MarshallChristopher M Overall
Jan 1, 1971·Acta Pathologica Et Microbiologica Scandinavica. Section B: Microbiology and Immunology·T Wadstrom, O Vesterberg
Jun 13, 1998·Antimicrobial Agents and Chemotherapy·M W ClimoG L Archer

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