Dec 22, 1999

Lysozyme association with nucleic acids

Biochemical and Biophysical Research Communications
L K STEINRAUFM Y Chiang

Abstract

Lysozyme is well known for the ability to hydrolyze the cell wall of bacteria. Based on the similarity of structure between lysozyme and histones as seen from the results of X-ray crystal structure determinations, we have postulated that binding to nucleic acids may be another biological function of lysozyme. We have therefore begun a systematic study of the interactions of lysozyme and related molecules with nucleic acids, and present here a preliminary report. Binding to DNA and RNA has been demonstrated from gel electrophoresis, enzyme activity, and coprecipitation studies. We suggest that this function of lysozyme will provide an explanation why Lee-Huang et al. (1999) [Proc. Natl. Acad. Sci. USA 96, 2678-2681] were able to call lysozyme a "killer protein" against the AIDS virus, and may provide a new avenue of research on AIDS therapy.

  • References6
  • Citations15

Mentioned in this Paper

Activated T Cell Autonomous Cell Death
SDS-PAGE
Plain X-ray
Lysozyme Test
Egg White Proteins
LYZ
Endonuclease MkiI
Lysozyme
Enzyme Activity
Muramidase

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