Lysyl oxidase: A colorectal cancer biomarker of lung and hepatic metastasis

Thoracic Cancer
Yun LiuLong Cui

Abstract

Colorectal cancer (CRC) is a common and lethal disease in which distant metastasis remains the primary cause of death. Paradoxical roles of LOX have been reported in CRC, and the intracellular function of LOX has also recently been determined. Correlations of LOX expression and its intracellular localization with clinicopathological features in CRC patients remain largely unknown. The aim of the present study was to explore the potential roles of LOX in CRC. LOX messenger RNA expression was assayed by quantitative PCR in eight paired normal mucosa and tumor tissues. Immunohistochemistry was conducted using tissue arrays to investigate LOX expression in 201 CRC patients. Regulation of LOX by YAP and TEAD4 was explored by YAP or TEAD4 short hairpin RNA interference in a LoVo cell line. LOX messenger RNA expression was elevated in some CRC specimens, and LOX nuclear localization was detected in CRC tumor tissues. LOX nuclear localization was found to correlate with lung/hepatic metastasis, elevated serum carcinoembryonic antigen concentration, and mucinous tumor type (P < 0.05). Nuclear LOX expression was found to be associated with poor overall and disease-free survival (P < 0.05), and postoperative lung/hepatic metastasis (P < 0...Continue Reading

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Citations

Nov 23, 2019·Biochemical Society Transactions·Jessica L ChittyThomas R Cox
May 20, 2020·Annals of the New York Academy of Sciences·Hadi GhasemiHeidar Tavilani
Apr 25, 2020·Cells·Heinrich KovarBranka Radic-Sarikas
May 7, 2019·World Journal of Gastroenterology : WJG·Ya-Lin HanGuang-Hai Dai
Aug 28, 2021·Communications Biology·Laura Martinez-VidalMassimo Alfano

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Methods Mentioned

BETA
surgical resection
PCR
X‐ray
electrophoresis

Software Mentioned

SPSS

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