Lysyl oxidase activity in the mouse uterine cervix is physiologically regulated by estrogen

Endocrinology
H OzasaT Takeda

Abstract

Lysyl oxidase activity in the mouse cervix was examined during the estrous cycle, pregnancy, and the postpartum period. It was highest in estrus and lowest in diestrus. On day 1 of pregnancy, the activity was comparable to that seen in estrus. It then declined continuously until day 17 of pregnancy, when it was approximately equal to that seen during diestrus. The activity showed a slight increase toward term, then a precipitous increase occurred on the first postpartum day. The activity fell by the seventh postpartum day to a value comparable to that seen in diestrus. Enzyme activity fell to one fourth of its former value 3 days after ovariectomy. The injection of 1 microgram 17 beta-estradiol or more in 0.9% NaCl 10 days after ovariectomy raised the activity, in 18 h, to the level seen in estrus. One milligram of progesterone had no effect on the enzyme activity, but a combination of 1 microgram 17 beta-estradiol and 1 mg progesterone raised the activity to that seen with 1 microgram 17 beta-estradiol alone. These results suggest that lysyl oxidase activity in the mouse cervix is under the control of estrogen.

Citations

Jun 2, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M SaitoA Shinohara
Sep 18, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M Saito, K Marumo
Dec 4, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sara ContenteRobert M Friedman
Nov 1, 1990·Cell and Tissue Kinetics·G S EvansC S Potten
Feb 22, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Mala Mahendroo
Jul 31, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Charles P ReadMala S Mahendroo
Mar 14, 2014·Current Osteoporosis Reports·Mitsuru SaitoKeishi Marumo
May 13, 2010·Journal of Biomedical Optics·Meredith L AkinsMala Mahendroo
Feb 23, 2010·Trends in Endocrinology and Metabolism : TEM·Brenda TimmonsMala Mahendroo
Jul 31, 2013·IEEE Transactions on Bio-medical Engineering·Mozziyar EtemadiShuvo Roy
Mar 21, 2015·Calcified Tissue International·Mitsuru Saito, Keishi Marumo
Oct 24, 2003·Biochimica Et Biophysica Acta·Sergio WittlinGeoffrey J Lindeman
Sep 6, 2019·Interface Focus·Kyoko YoshidaKristin M Myers
May 5, 2000·Medicine and Science in Sports and Exercise·T LeGrosA H Burns
Aug 12, 2017·PloS One·Christopher R HarlowStephen G Hillier
Jul 27, 2021·Biology of Reproduction·Shanmugasundaram NallasamyMala Mahendroo

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