PMID: 883816Jul 1, 1977Paper

Lytic effect of mycobacillin and its derivatives on erythrocytes

Antimicrobial Agents and Chemotherapy
P C Banerjee

Abstract

Mycobacillin as well as its O-acetyl (tyrosyl and seryl) and ester derivatives is known to have antifungal activity. The antibiotic also possesses hemolytic activity. This latter property is not appreciably altered by partial or complete esterification of its free carboxyl groups. On the other hand, acetylation of the molecule at the two tyrosyl hydroxyl groups nullifies selectively the hemolytic activity.

References

Jan 11, 1958·Nature·S K MAJUMDAR, S K BOSE
Sep 1, 1960·Archives of Biochemistry and Biophysics·S K MAJUMDAR, S K BOSE

Related Concepts

Acetylation
Antibiotics, Antifungal
Hemolysis
Mycobacillin
Structure-Activity Relationship

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