Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture

Nature Medicine
R RenneD Ganem

Abstract

Kaposi's sarcoma (KS) is the leading neoplasm of AIDS patients, and HIV infection is known to be a major risk factor for its development. However, KS can occur in the absence of HIV infection and the risk of KS development varies widely even among HIV-infected patients, with homosexual men with AIDS being 20 times more likely to develop KS than AIDS-afflicted children or hemophiliacs. These and other data strongly suggest that a sexually transmitted agent or co-factor may be involved in KS pathogenesis. Recently, DNA sequences corresponding to the genome of a novel member of the herpesvirus family have been identified within AIDS-KS biopsies, and several reports indicate that these sequences are also present in all forms of HIV-negative KS. These and other findings suggest this new agent, referred to as KS-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV8), as a candidate for the putative etiologic cofactor. However, the role of this agent in KS remains hotly debated. Further progress in understanding its biology has been severely hampered by the lack of a cell culture system for virus growth. Here we report the development of a system for the lytic growth of this virus in a latently infected B cell line and present th...Continue Reading

References

Jan 20, 1990·Lancet·A E Friedman-KienT A Peterman
Jan 1, 1991·Health Affairs·M V PaulyJ Hoff
Aug 15, 1981·International Journal of Cancer. Journal International Du Cancer·S A Ben-Sasson, G Klein
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M Hummel, E Kieff
Jan 15, 1984·International Journal of Cancer. Journal International Du Cancer·K Takada
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
May 1, 1994·Current Biology : CB·J J Rossi
May 1, 1995·Current Biology : CB·D Ganem
Jul 1, 1995·Nature Medicine·M SchallingP Biberfeld
May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
Mar 25, 1995·Lancet·Y Q HuangA E Friedman-Kien

❮ Previous
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Citations

Dec 16, 1997·The Prostate·R MunkerH P Koeffler
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·M StürzlP Biberfeld
Dec 6, 1997·International Journal of Cancer. Journal International Du Cancer·A CarboneG Gaidano
Sep 1, 1996·Reviews in Medical Virology·A F Voevodin
Sep 13, 2002·Journal of Medical Virology·Jian SongNorihiro Nishimoto
May 22, 2001·Journal of Medical Virology·E B QuinlivanUNKNOWN Swiss HIV Cohort Study
Jul 4, 2007·Pathology Oncology Research : POR·Márta CsireIstván Vályi-Nagy
Oct 19, 2007·Archives of Virology·N CloutierL Flamand
Apr 23, 2013·International Journal of Hematology·Hiroki GotoSeiji Okada
Apr 28, 2012·The Journal of Microbiology·Hyosun Cho, Hyojeung Kang
Oct 1, 1996·Trends in Microbiology·M K Offermann
May 6, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Bhavna H ChohanRhoda Ashley Morrow
May 5, 2001·Journal of Virological Methods·A JuhászL Gergely
Feb 1, 1997·Journal of Virological Methods·M J LockV C Emery
Aug 26, 1998·Antiviral Research·J W Cohen StuartR J Whitley
May 22, 1998·Trends in Genetics : TIG·P S Moore, Y Chang
Apr 19, 2002·Biochimica Et Biophysica Acta·Richard G Jenner, Chris Boshoff
Jul 3, 1999·Trends in Microbiology·B Herndier
Apr 20, 2001·The International Journal of Biochemistry & Cell Biology·F BussolinoB Ensoli
Apr 28, 2001·Cytokine & Growth Factor Reviews·J ChoiJ U Jung
Jul 11, 1998·Oral Oncology·S R PorterN Kumar
Aug 15, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·L WuB Forghani
Mar 30, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·S MuralidharL J Rosenthal
Mar 30, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·D C EdelmanN T Constantine
Aug 1, 1996·Nature Medicine·J J O'Leary

❮ Previous
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