M antigens of group A streptococci isolated by means of immunochromatography. Biochemical and serological properties

Immunobiology
O KühnemundJ Sjöquist

Abstract

M proteins of Streptococcus pyogenes types 1 and 12 were purified by immunochromatography on immobilized type-specific opsonizing antibodies. The M proteins were characterized serologically and biochemically. They absorb after immobilization opsonizing antibodies and only precipitate with homologous antisera in immunodiffusion. In SDS PAGE they show one main band, corresponding to mol. weights of 5 X 104 (type 1) and 5.4 X 104 (type 12), accompanied by faint lines, which form with the main band a precipitation line of identity in SDS-crossed immunoelectrophoresis. Both M proteins aggregate blood platelets and clot fibrinogen.

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E H BeacheyA H Kang
Aug 4, 1972·European Journal of Biochemistry·R GollwitzerH Furthmayr
Oct 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·E N Fox, M K Wittner

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Citations

Feb 1, 1984·European Journal of Clinical Microbiology·H Miörner, K N Larsson
Mar 1, 1988·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·O KühnemundW Köhler
Jul 1, 1984·Scandinavian Journal of Immunology·L BjörckR Sundler
Nov 1, 1994·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·C PrietoJ M Castro
Nov 19, 2011·FEMS Microbiology Letters·Kaicheng WangChengping Lu
Aug 10, 2012·Journal of Clinical Microbiology·Kaicheng WangChengping Lu
Jun 1, 1985·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·O KühnemundW Köhler

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