M-cadherin-mediated cell adhesion and complex formation with the catenins in myogenic mouse cells

Experimental Cell Research
C KuchA Starzinski-Powitz

Abstract

M-cadherin is a member of the multigene family of calcium-dependent intercellular adhesion molecules, the cadherins, which are involved in morphogenetic processes. Amino acid comparisons between M-cadherin and E-, N-, and P-cadherin suggested that M-cadherin diverged phylogenetically very early from these classical cadherins. It has been shown that M-cadherin is expressed in prenatal and adult skeletal muscle. In the cerebellum, M-cadherin is present in an adherens-type junction which differs in its molecular composition from the E-cadherin-mediated adherens-type junctions. These and other findings raised the question of whether M-cadherin and the classical cadherins share basic biochemical properties, notably the calcium-dependent resistance to proteolysis, mediation of calcium-dependent intercellular adhesion, and the capability to form M-cadherin complexes with the catenins. Here we show that M-cadherin is resistant to trypsin digestion in the presence of calcium ions but at lower trypsin concentrations than E-cadherin. When ectopically expressed in LMTK- cells, M-cadherin mediated calcium-dependent cell aggregation. Finally, M-cadherin was capable of forming two distinct cytoplasmic complexes in myogenic cells, either with ...Continue Reading

References

Nov 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Y Pouliot
Jan 1, 1992·Annual Review of Cell Biology·B Geiger, O Ayalon
Feb 1, 1992·The Journal of Cell Biology·M Ozawa, R Kemler
Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M DonaliesA Starzinski-Powitz
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K HerrenknechtR Kemler
May 1, 1991·The Journal of Cell Biology·E W NapolitanoL F Reichardt
Jan 1, 1990·Annual Review of Biochemistry·M Takeichi
Apr 1, 1990·The Journal of Cell Biology·J L Bixby, R Zhang
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M OzawaR Kemler
Aug 11, 1989·Science·S MiyataniM Takeichi
Apr 1, 1973·Virology·F L Graham, A J van der Eb
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·D L RimmJ S Morrow
Jun 20, 1995·Proceedings of the National Academy of Sciences of the United States of America·O RoseW W Franke
Oct 1, 1994·Current Opinion in Cell Biology·J HülskenW Birchmeier
Nov 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·O RoseA Starzinski-Powitz
Mar 23, 1995·Nature·L ShapiroW A Hendrickson
Aug 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y PouliotP C Holland
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·L LarueR Kemler
Jun 1, 1994·The Anatomical Record·A Bornemann, H Schmalbruch
Apr 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A IrintchevA Wernig
Jan 1, 1993·Journal of Cell Science. Supplement·B M Gumbiner, P D McCrea
Dec 10, 1993·Science·B RubinfeldP Polakis
Jan 1, 1994·Developmental Biology·C Murphy-ErdoshL F Reichardt

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Citations

May 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elena VasyutinaCarmen Birchmeier
Nov 18, 2005·Molecular Biology of the Cell·Sophie CharrasseCécile Gauthier-Rouvière
Mar 3, 2007·Molecular Biology of the Cell·Sophie CharrasseCécile Gauthier-Rouvière
Jun 8, 2002·Molecular and Cellular Biology·Angela HollnagelHans-Henning Arnold
Jul 17, 1998·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·J E Anderson
Aug 16, 2002·Physiological Genomics·Jennifer L MoranChristopher P Miller
Jan 13, 2004·Physiological Reviews·Sophie B P Chargé, Michael A Rudnicki
Nov 8, 2011·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Pierre-Yves RescanVeronique Lebret
Jan 6, 2021·International Journal of Molecular Sciences·Daniel J OwensCatherine Coirault
Sep 21, 2013·Journal of Cell Science·Merce MartiJuan Carlos Izpisua Belmonte
Apr 10, 2008·Journal of Cell Science·Ana Perez-RuizPeter S Zammit
Jan 16, 2007·European Journal of Cell Biology·Edyta WróbelJerzy Moraczewski

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