PMID: 107463Jan 1, 1979

M components and cancer

Neoplasma
M MunzarováA Kubíková-Kourilová

Abstract

Intention of this study was to prove or exclude in patients with different neoplasms some M components which can escape routine electrophoretic analysis or immunoelectrophoretic analysis with polyvalent antiserum. All serum samples from 606 patients were investigated also with monospecific antisera against heavy chains--alpha, gamma, mu and delta--and in suspicion of abnormality also with antisera against light chains. Patterns similar to those found in cases of heavy chain diseases were absent in all patients. M components of IgD class were not found, as well. As to M components of usual types a relatively high incidence was found in lymphoproliferative malignancies excluded myelomas or Waldenstroöm's macroglobulinemias (5.61% in adults and 2.32% in children). On the basis of results the importance of immunoelectrophoretical analysis with monospecific antisera in all these cases is pointed out; not only in attempt to discover additional subjects of heavy chain diseases but also to detect mild "macroglobulinemic" abnormalities which may not be so far detected on electrophoretical pattern.

Related Concepts

IgA2
Polyglobin
IgM2
Kappa-Immunoglobulin Subgroup VK-21
Lambda-x Immunoglobulin
Leukemia
Lymphoma
Malignant Neoplasms
Paraproteins

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