Abstract
Peripheral nerve damage is the hallmark of leprosy pathology but its etiology is unclear. We previously identified the membrane attack complex (MAC) of the complement system as a key determinant of post-traumatic nerve damage and demonstrated that its inhibition is neuroprotective. Here, we determined the contribution of the MAC to nerve damage caused by Mycobacterium leprae and its components in mouse. Furthermore, we studied the association between MAC and the key M. leprae component lipoarabinomannan (LAM) in nerve biopsies of leprosy patients. Intraneural injections of M. leprae sonicate induced MAC deposition and pathological changes in the mouse nerve, whereas MAC inhibition preserved myelin and axons. Complement activation occurred mainly via the lectin pathway and the principal activator was LAM. In leprosy nerves, the extent of LAM and MAC immunoreactivity was robust and significantly higher in multibacillary compared to paucibacillary donors (p = 0.01 and p = 0.001, respectively), with a highly significant association between LAM and MAC in the diseased samples (r = 0.9601, p = 0.0001). Further, MAC co-localized with LAM on axons, pointing to a role for this M. leprae antigen in complement activation and nerve damage ...Continue Reading
References
Dec 1, 1985·Infection and Immunity·S LaalI Nath
Apr 1, 1971·International Journal of Dermatology·A S SohiN Singh
Jun 11, 1999·The American Journal of Pathology·C VerhagenP Das
Apr 5, 2001·The New England Journal of Medicine·M J Walport
Apr 12, 2001·The New England Journal of Medicine·M J Walport
Apr 10, 2002·Journal of the Peripheral Nervous System : JPNS·Guido StollRobert R Myers
May 4, 2002·Science·Anura RambukkanaJames L Salzer
Nov 15, 2002·The European Journal of Neuroscience·Christine LeonhardReinhard Kiefer
Apr 15, 2006·Clinical Microbiology Reviews·D M ScollardD L Williams
Jul 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Valeria RamagliaFrank Baas
Mar 20, 2008·The American Journal of Pathology·Valeria RamagliaFrank Baas
Oct 25, 2008·Molecular Immunology·Marieta M RusevaB Paul Morgan
Feb 28, 2009·Molecular Immunology·Valeria RamagliaFrank Baas
Oct 17, 2009·Molecular Immunology·Valeria RamagliaFrank Baas
Apr 22, 2010·Neuroimmunomodulation·Carlos Rodrigo Cámara-LemarroyNancy Esthela Fernández-Garza
Aug 16, 2013·Current Opinion in Neurology·Christian J M Sindic
Citations
Sep 22, 2015·Expert Review of Clinical Immunology·Bryan Paul Morgan
Feb 19, 2016·Journal of Neuropathology and Experimental Neurology·Priscila Ribeiro AndradeEuzenir Nunes Sarno
Apr 9, 2016·Journal of Neuroinflammation·Nawal Bahia El IdrissiDirk Troost
Jun 4, 2016·Plastic and Reconstructive Surgery. Global Open·Eric L WanA Lee Dellon
May 5, 2016·International Journal of Medical Microbiology : IJMM·Anna S ŚwierzkoMaciej Cedzyński
Jan 11, 2016·Clinical and Experimental Immunology·N Bahia El IdrissiF Baas
Aug 23, 2016·The Journal of Infection·J W Neal, P Gasque
May 16, 2017·PloS One·Nawal Bahia El IdrissiPranab K Das
Mar 23, 2018·PLoS Neglected Tropical Diseases·Débora Santos da SilvaFlavio Alves Lara
Jul 28, 2018·Pathogens and Disease·Héctor Serrano-CollNora Cardona-Castro
Feb 27, 2020·Seminars in Immunopathology·Katharina RöltgenCharlotte Avanzi
May 4, 2018·Pathogens and Disease·Joanne Turner, Jordi B Torrelles
Aug 14, 2020·Ciência & saúde coletiva·Carlos Dornels Freire de SouzaCarlos Feitosa Luna
May 5, 2018·Acta Neuropathologica Communications·Iliana MichailidouFrank Baas
Jun 16, 2018·Frontiers in Immunology·André Alan NahasLuiz Ricardo Goulart
May 16, 2019·Anais Brasileiros De Dermatologia·Carlos Dornels Freire de SouzaMônica de Avelar Figueiredo Mafra Magalhães
Apr 5, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·W Alemu Belachew, B Naafs
May 28, 2019·International Journal of Experimental Pathology·Fátima Regina Vilani-MorenoSílvia Cristina Barboza Pedrini
Nov 30, 2019·Journal of Immunology Research·Douglas Eulálio AntunesLuiz Ricardo Goulart
Apr 13, 2018·Frontiers in Immunology·Roberta Olmo PinheiroEuzenir Nunes Sarno
Jan 28, 2021·Medicina·Heena Jagatia, Anthony G Tsolaki
Jan 1, 2019·Anais Brasileiros De Dermatologia·Carlos Dornels Freire de SouzaMônica de Avelar Figueiredo Mafra Magalhães
Mar 13, 2021·Immunological Reviews·Anouk van Hooij, Annemieke Geluk