M-octopamine injected into the paraventricular nucleus induces eating in rats: a comparison with noradrenaline-induced eating

British Journal of Pharmacology
P J Fletcher, I A Paterson

Abstract

1. The effects on food intake in rats of injection of m- and p-octopamine into the paraventricular nucleus (PVN) of the hypothalamus were examined, and compared to the effects of noradrenaline (NA). 2. m-Octopamine injected into the PVN induced a dose-dependent increase in food intake, with the maximal effect occurring at a dose of 25 nmol. p-Octopamine did not elicit eating unless it was administered to animals pretreated with the monoamine oxidase inhibitor, pargyline. 3. The effects of pretreatment with various adrenoceptor antagonists, injected into the PVN, on the eating responses induced by 25 nmol m-octopamine and NA were examined. The alpha 1-adrenoceptor antagonist, corynanthine, and the beta-adrenoceptor antagonist, propranolol, failed to alter the eating induced by m-octopamine or NA. The effects of these two amines were susceptible to blockade of alpha 2-adrenoceptors. Idazoxan reversed the eating induced by m-octopamine and noradrenaline. However, yohimbine was effective only against the eating induced by m-octopamine. Thus, both m-octopamine and NA appear to act via alpha 2, but not alpha 1 or beta-adrenoceptors. 4. Injection of alpha-methyl-p-tyrosine into the PVN attenuated the effect of m-octopamine, but not of...Continue Reading

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