M100907, a selective 5-HT(2A) receptor antagonist, attenuates phencyclidine-induced Fos expression in discrete regions of rat brain

European Journal of Pharmacology
T HabaraS Kuroda

Abstract

5-HT and dopamine receptor antagonists have become widely used as atypical antipsychotics. Although 5-HT(2A) receptor antagonistic activity is thought to contribute to the atypical aspects of these agents, the precise mechanism remains unknown. M100907 (R(+)-alpha(2,3-dimethoxyphenyl)-1-[2(4-fluorophenyl)ethyl)]-4-piperidine -methanol), a selective 5-HT(2A) receptor antagonist, is reported to attenuate phencyclidine (PCP)-induced locomotion in rodents. For the purpose of identifying regions in which M100907 exerts its effect, we investigated the effects of M100907 on PCP-induced Fos expression in rat brain. PCP (5 mg/kg, subcutaneously, s.c.) induced Fos expression in the cingulate cortex area 3, the agranular insular cortex, the piriform cortex, the nucleus accumbens, the anterior paraventricular thalamic nucleus and the ventral lateral septal nucleus. Pretreatment with M100907 (0.5 mg/kg, s.c.) attenuated Fos expression induced by PCP in the nucleus accumbens core, the shell, the agranular insular cortex and the piriform cortex. M100907 did not induce Fos expression in any of the regions investigated including the dorsolateral caudate/putamen when given alone. These results indicate that 5-HT(2A) receptor antagonism attenuate...Continue Reading

References

Mar 14, 1991·The New England Journal of Medicine·R J Baldessarini, F R Frankenburg
Aug 15, 1991·The New England Journal of Medicine·L J FriedmanM Sved
Sep 1, 1989·Journal of Neuroscience Methods·M Dragunow, R Faull
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Apr 1, 1994·Brain Research. Molecular Brain Research·M PompeianoG Mengod
Jan 1, 1996·Behavioural Brain Research·P C MoserJ H Kehne
Feb 24, 1998·European Journal of Pharmacology·M A ScheidelerA Fink-Jensen

❮ Previous
Next ❯

Citations

Jul 8, 2005·Psychopharmacology·Charles H LargeDonald C Goff
Dec 6, 2005·Psychopharmacology·C A JenningsE Southam
May 6, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carli MirjanaClaudia Balducci
Aug 7, 2004·Brain Research. Brain Research Reviews·Teige P SheehanDavid S Russell
Aug 31, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ce Zhang, Gerard J Marek

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.