M1hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer.

Journal for Immunotherapy of Cancer
Eva M Garrido-MartinTilman Sanchez-Elsner

Abstract

The role of tumor-associated macrophages (TAMs) in determining the outcome between the antitumor effects of the adaptive immune system and the tumor's anti-immunity stratagems, is controversial. Macrophages modulate their activities and phenotypes by integration of signals in the tumor microenvironment. Depending on how macrophages are activated, they may adopt so-called M1-like, antitumor or M2-like, protumor profiles. In many solid tumors, a dominance of M2-like macrophages is associated with poor outcomes but in some tumor types, strong M1-like profiles are linked to better outcomes. We aimed to investigate the interrelationship of these TAM populations to establish how they modulate the efficacy of the adaptive immune system in early lung cancer. Macrophages from matched lung (non-tumor-associated macrophages (NTAMs)) and tumor samples (TAMs) from resected lung cancers were assessed by bulk and single-cell transcriptomic analysis. Protein expression of genes characteristic of M1-like (chemokine (C-X-C motif) ligand 9) or M2-like (matrix metallopeptidase 12) functions was confirmed by confocal microscopy. Immunohistochemistry related the distribution of TAM transcriptomic signatures to density of CD8+ tissue-resident memory ...Continue Reading

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Citations

Feb 28, 2021·Journal for Immunotherapy of Cancer·Paola Marie MarcovecchioShahram Salek-Ardakani
Apr 4, 2021·International Journal of Molecular Sciences·Galina F MedvedevaMarina S Dukhinova
May 15, 2021·Thorax·Sebastian T LuggDavid R Thickett
Apr 23, 2021·Journal of the Chinese Medical Association : JCMA·Zhi-Xiong ChongHan-Kiat Ong
Jul 21, 2021·International Journal of Molecular Sciences·Pedram Moeini, Paulina Niedźwiedzka-Rystwej
Aug 28, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xuan HanPeng Cao

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Datasets Mentioned

BETA
GSE116948
GM-CSF

Methods Mentioned

BETA
surgical resection
Fluorescent Activated Cell Sorting
FACS
PCR
chips
Confocal Microscopy
RNA-seq
PCA
flow cytometry
scraping

Software Mentioned

Ingenuity Pathway Analysis tool ( IPA
DESeq2
TopHat
SAMtools
HTSeq
IPA
Bioconductor
Rtsne
Qlucore
R scripts

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