M1/M2 macrophage polarization in human obese adipose tissue

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Jaroslava ChylikovaVojtech Kamarad

Abstract

Obesity and insulin resistance are closely associated with chronic inflammation in adipose tissue, where macrophages play an important role. Adipose tissue macrophages can be divided into two main phenotypes: the classical M1 macrophages and alternatively activated macrophages M2. M1 macrophages produce pro-inflammatory cytokines (TNF-α, interleukin IL-6 and MCP-1) and thus contribute to the development of insulin resistance. On the other hand, M2 macrophages, anti-inflammatory, are involved in the maintenance of tissue homeostasis and are typical in the adipose tissue of slender individuals. Macrophages can also play a role in the pathogenesis of other serious illnesses such as cardiovascular diseases or cancer. This article reviews the latest data on macrophage polarization in adipose tissue.

References

Nov 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S Gordon
Aug 27, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Takayoshi SuganamiYoshihiro Ogawa
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Mar 31, 2007·Diabetes·Naomi HosogaiIichiro Shimomura
Aug 2, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jianping YeQing He
Sep 13, 2007·Diabetes·Katherine J StrisselMartin S Obin
Oct 25, 2007·Cell·Stephane GestaC Ronald Kahn
Feb 14, 2008·American Journal of Physiology. Endocrinology and Metabolism·Jukka WesterbackaHannele Yki-Järvinen
May 14, 2008·Current Pharmaceutical Design·Leonie K Heilbronn, Lesley V Campbell
Aug 4, 2010·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Olga T HardyMichael P Czech
Sep 30, 2010·The Journal of Clinical Investigation·Aliki KosteliAnthony W Ferrante
Jun 3, 2011·The Journal of Clinical Investigation·Kai SunPhilipp E Scherer
Jan 19, 2016·Frontiers in Immunology·Angela CastoldiPedro M Moraes-Vieira
Sep 11, 2017·Biochemical and Biophysical Research Communications·Qian GuoNing Gu

❮ Previous
Next ❯

Citations

Feb 16, 2019·Current Stem Cell Research & Therapy·Lingbo KongDingjun Hao
Nov 27, 2019·International Journal of Molecular Sciences·Sung-Min HwangChul-Kyu Park
May 6, 2020·Biomedicines·Blair Z JohnsonFiona M Wood
Jun 3, 2020·American Journal of Physiology. Endocrinology and Metabolism·Qingyi JiaMichael D Jensen
Dec 24, 2018·Journal of Leukocyte Biology·Le-Xun WangJiao Guo
Sep 24, 2020·International Journal for Parasitology·Shin Ae KangHak Sun Yu
Jan 20, 2021·Diabetes, Obesity & Metabolism·Bertrand CariouArun J Sanyal
Feb 8, 2020·Journal of the American College of Cardiology·Jeffrey I MechanickW Timothy Garvey
Jan 9, 2021·Biomarker Research·Qi WuShengrong Sun
Nov 27, 2020·Frontiers in Cardiovascular Medicine·Alexander E BerezinMichael Lichtenauer
May 1, 2021·International Journal of Molecular Sciences·Ewa RudnickaBlazej Meczekalski
May 6, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Hyunju JeongHyunsu Bae
Jul 10, 2021·Cannabis and Cannabinoid Research·Eulla Keimili Fernandes Ferreira CavalheiroGislaine Tezza Rezin
Jul 15, 2021·Vascular·Jingsong CaoJianghua Liu
Oct 31, 2020·Cancer Letters·Jian YangHanxiang Zhan
Aug 23, 2021·The Journal of Nutritional Biochemistry·Sabrina FolieSusanne Kaser
May 6, 2021·Physiological Reviews·Jun RenYingmei Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here