MAb 806 enhances the efficacy of ionizing radiation in glioma xenografts expressing the de2-7 epidermal growth factor receptor

International Journal of Radiation Oncology, Biology, Physics
Terrance G JohnsAndrew M Scott

Abstract

Mutations of the epidermal growth factor receptor (EGFR) are common in glioma. The most frequent mutation, de2-7 EGFR/EGFRvIII, occurs in approximately 40% of high-grade gliomas and confers resistance to ionizing radiation (IR). We have previously shown that mAb 806, a novel EGFR-specific antibody, is able to inhibit the growth of U87MG.Δ2-7 glioma xenografts expressing the de2-7 EGFR and may have potential as a therapeutic. Nude mice bearing U87MG.Δ2-7 xenografts were treated with mAb 806 and/or IR. Comparison of tumor volumes, the effect of treatment on angiogenesis as determined by mean vessel density, and expression changes in prosurvival protein pAkt between treatment groups were undertaken. Treatment of mice bearing U87MG.Δ2-7 xenografts with mAb 806 and IR resulted in schedule-dependent radiosensitization. Maximal benefit was obtained when antibody treatment was given before irradiation, with the greatest inhibition of both tumor angiogenesis and tumor growth. Combination treatment mediated radiosensitization by selectively blocking the phosphorylation of the prosurvival protein Akt at serine 473, a process that is independent of DNA-dependent protein kinase catalytic subunit. Our results provide a rationale for the use ...Continue Reading

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A J EkstrandV P Collins
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N SugawaV P Collins
Dec 2, 1999·Genes & Development·S R DattaM E Greenberg
Jun 28, 2001·Oncogene·J Mendelsohn, J Baselga
Aug 16, 2001·Journal of the National Cancer Institute·J S SmithR B Jenkins
Jan 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Achim A JungbluthWebster K Cavanee
Aug 29, 2003·Oncogene·Guido LammeringRupert K Schmidt-Ullrich
Dec 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Terrance G JohnsAndrew M Scott
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chris A LearnJohn H Sampson
Jul 21, 2004·The Journal of Biological Chemistry·Jianhua FengBrian A Hemmings
Oct 7, 2004·Cancer Biology & Therapy·Alfredo VelascoFredrick S Leach
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Guido LammeringRupert K Schmidt-Ullrich
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amy B HeimbergerKenneth Aldape
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jun 16, 2005·Journal of the National Cancer Institute·Daphne A Haas-KoganDavid Stokoe
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amir AbdollahiPeter E Huber
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rushika M PereraTerrance G Johns
Nov 3, 2005·Nature Clinical Practice. Oncology·Carolyn I Sartor
Nov 12, 2005·The New England Journal of Medicine·Ingo K MellinghoffPaul S Mischel
Mar 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David A ReardonDarell D Bigner
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andrew M ScottLloyd J Old
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Terrance G JohnsFrank B Furnari
May 22, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sherry A WepplerGuido Lammering

❮ Previous
Next ❯

Citations

Mar 7, 2012·Cold Spring Harbor Perspectives in Medicine·Shom GoelRakesh K Jain
Jul 12, 2011·Physiological Reviews·Shom GoelRakesh K Jain
Dec 18, 2012·Expert Opinion on Biological Therapy·Yujiong WangWilliam C Cho
Mar 20, 2014·Growth Factors·Antony W BurgessYosef Yarden
Aug 28, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Henri WichmannDirk Vordermark
May 7, 2015·Pharmacology & Therapeutics·Constantinos Alifieris, Dimitrios T Trafalis
Jun 27, 2017·Cancer Letters·Ju YangBaorui Liu
Feb 23, 2019·Neurologia Medico-chirurgica·Takanori NozawaAkiyoshi Kakita
Jan 14, 2021·International Journal of Molecular Sciences·Alexandru OpritaAni-Simona Sevastre

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.