Macaque parvocellular mediodorsal thalamus: dissociable contributions to learning and adaptive decision-making.

The European Journal of Neuroscience
Subhojit ChakrabortyAnna S Mitchell

Abstract

Distributed brain networks govern adaptive decision-making, new learning and rapid updating of information. However, the functional contribution of the rhesus macaque monkey parvocellular nucleus of the mediodorsal thalamus (MDpc) in these key higher cognitive processes remains unknown. This study investigated the impact of MDpc damage in cognition. Preoperatively, animals were trained on an object-in-place scene discrimination task that assesses rapid learning of novel information within each session. Bilateral neurotoxic (NMDA and ibotenic acid) MDpc lesions did not impair new learning unless the monkey had also sustained damage to the magnocellular division of the MD (MDmc). Contralateral unilateral MDpc and MDmc damage also impaired new learning, while selective unilateral MDmc damage produced new learning deficits that eventually resolved with repeated testing. In contrast, during food reward (satiety) devaluation, monkeys with either bilateral MDpc damage or combined MDpc and MDmc damage showed attenuated food reward preferences compared to unoperated control monkeys; the selective unilateral MDmc damage left performance intact. Our preliminary results demonstrate selective dissociable roles for the two adjacent nuclei of...Continue Reading

References

Nov 1, 1991·The Journal of Comparative Neurology·H BarbasC R Dermon
Jul 15, 1991·The Journal of Comparative Neurology·M L SchwartzP S Goldman-Rakic
Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Mar 8, 1987·The Journal of Comparative Neurology·T M Preuss, P S Goldman-Rakic
Jun 22, 1994·The Journal of Comparative Neurology·C R Dermon, H Barbas
Jul 1, 1997·Experimental Brain Research·J BachevalierL G Ungerleider
May 5, 1999·Nature·L Tremblay, W Schultz
Feb 26, 2000·Neuropsychologia·Y D Van der WerfJ Jolles
Mar 24, 2000·Cerebral Cortex·C CavadaF Reinoso-Suárez
Jun 22, 2001·Nature·J D WallisE K Miller
Aug 8, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·S Haber, N R McFarland
Aug 23, 2003·Stroke; a Journal of Cerebral Circulation·Jeremy D Schmahmann
Aug 13, 2004·Journal of Neurophysiology·Ikuo Tanibuchi, Patricia S Goldman-Rakic
Aug 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alicia IzquierdoElisabeth A Murray
Apr 27, 2005·Cognitive, Affective & Behavioral Neuroscience·Shintaro FunahashiYumiko Watanabe
Nov 10, 2006·Nature·Marc A Sommer, Robert H Wurtz
Apr 21, 2007·The European Journal of Neuroscience·Charles R E WilsonMark G Baxter
Sep 12, 2007·Annals of the New York Academy of Sciences·Matthew R Roesch, Carl R Olson
Oct 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna S MitchellMark G Baxter
Oct 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark G BaxterAnna S Mitchell
Nov 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna S MitchellDavid Gaffan
Jan 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna S Mitchell, David Gaffan
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip G F Browning, David Gaffan
Apr 16, 2008·Behavioral Neuroscience·Philip G F Browning, David Gaffan
Jul 1, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·David Gaffan, Charles R E Wilson
Aug 22, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna S MitchellDavid Gaffan
Oct 28, 2008·Brain Research Bulletin·Suzanne N Haber, Roberta Calzavara
Oct 9, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzanne N Haber, Brian Knutson
May 25, 2011·Neuroscience and Biobehavioral Reviews·Yumiko Watanabe, Shintaro Funahashi
Mar 26, 2013·Neuron·Sebastien ParnaudeauChristoph Kellendonk
Aug 21, 2013·Frontiers in Systems Neuroscience·Anna S Mitchell, Subhojit Chakraborty
May 13, 2014·Biological Psychiatry·Sébastien ParnaudeauChristoph Kellendonk
Nov 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna S MitchellYogita Chudasama
Mar 7, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Cibu ThomasChris Baker
May 17, 2015·Cerebral Cortex·Philip G F BrowningAnna S Mitchell
Aug 28, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Clare Timbie, Helen Barbas

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Citations

Apr 11, 2019·The European Journal of Neuroscience·Carol A Mason, S Murray Sherman
Nov 28, 2020·Neuroscience and Biobehavioral Reviews·M WolffA Groh
Jul 4, 2021·Neuroscience and Biobehavioral Reviews·Brook A L PerryAnna S Mitchell

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