Macaques exhibit a naturally-occurring depression similar to humans

Scientific Reports
Fan XuPeng Xie

Abstract

Rodent models have dominated preclinical investigations into the mechanisms of depression. However, these models-which rely on subjecting individual rodents to physical stressors - do not realistically resemble the etiopathological development of depression, which occurs naturally in a social context. A non-human primate model that better reflects the social ethological aspects of depression would be more advantageous to investigating pathophysiological mechanisms and developing antidepressant therapeutics. Here, we describe and model a naturally-occurring depressive state in a non-human primate species, the cynomolgus monkey (Macaca fascicularis), in a realistic social ethological context and associate the depressed behavioral phenotype with significant serum metabolic perturbations. One to two subjects per stable social colony (17-22 subjects) manifested a depressive phenotype that may be attributed to psychosocial stress. In accordance with rodent and human studies, the serum metabolic phenotype of depressed and healthy subjects significantly differed, supporting the model's face validity. However, application of the fast-acting antidepressant ketamine failed to demonstrate predictive validity. This study proposes a non-huma...Continue Reading

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Citations

Dec 3, 2015·Behavioural Brain Research·Shuxiao ZhangPeng Xie
May 28, 2016·Neuroscience Research·Yukiori GotoEmanuel Jas
Jan 31, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·R BianchiE Laurent
Oct 3, 2020·Neuroscience and Biobehavioral Reviews·Eliza Bliss-Moreau, Peter H Rudebeck
Apr 10, 2021·Journal of Chemical Neuroanatomy·Danielle N Jones, Mary Ann Raghanti

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