Feb 4, 2020

Machine intelligence design of 2019-nCoV drugs

BioRxiv : the Preprint Server for Biology
Duc Duy NguyenGuowei Wei

Abstract

Wuhan coronavirus, called 2019-nCoV, is a newly emerged virus that infected more than 9692 people and leads to more than 213 fatalities by January 30, 2020. Currently, there is no effective treatment for this epidemic. However, the viral protease of a coronavirus is well-known to be essential for its replication and thus is an effective drug target. Fortunately, the sequence identity of the 2019-nCoV protease and that of severe-acute respiratory syndrome virus (SARS-CoV) is as high as 96.1%. We show that the protease inhibitor binding sites of 2019-nCoV and SARS-CoV are almost identical, which means all potential anti-SARS-CoV chemotherapies are also potential 2019-nCoV drugs. Here, we report a family of potential 2019-nCoV drugs generated by a machine intelligence-based generative network complex (GNC). The potential effectiveness of treating 2019-nCoV by using some existing HIV drugs is also analyzed.

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Mentioned in this Paper

Analysis
Peptide Hydrolases
Pharmacologic Substance
Protease Inhibitors
DNA Replication
Persons
Virus
SARS coronavirus
Human Immunodeficiency Virus Proteins
Coronaviridae

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