Machine Learning Analysis of Electronic Nose in a Transdiagnostic Community Sample With a Streamlined Data Collection Approach: No Links Between Volatile Organic Compounds and Psychiatric Symptoms

Frontiers in Psychiatry
Bohan XuMartin P Paulus

Abstract

Non-intrusive, easy-to-use and pragmatic collection of biological processes is warranted to evaluate potential biomarkers of psychiatric symptoms. Prior work with relatively modest sample sizes suggests that under highly-controlled sampling conditions, volatile organic compounds extracted from the human breath (exhalome), often measured by an electronic nose ("e-nose"), may be related to physical and mental health. The present study utilized a streamlined data collection approach and attempted to replicate and extend prior e-nose links to mental health in a standard research setting within large transdiagnostic community dataset (N = 1207; 746 females; 18-61 years) who completed a screening visit at the Laureate Institute for Brain Research between 07/2016 and 05/2018. Factor analysis was used to obtain latent exhalome variables, and machine learning approaches were employed using these latent variables to predict three types of symptoms independent of each other (depression, anxiety, and substance use disorder) within separate training and a test sets. After adjusting for age, gender, body mass index, and smoking status, the best fitting algorithm produced by the training set accounted for nearly 0% of the test set's variance....Continue Reading

References

Jun 1, 1986·Scandinavian Journal of Work, Environment & Health·H K Wilson
Oct 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·L PaulingP Cary
Jan 1, 1982·Addictive Behaviors·H A Skinner
Mar 14, 2001·Journal of Affective Disorders·E SuzukiM Asai
Sep 15, 2001·Journal of General Internal Medicine·K KroenkeJ B Williams
Oct 3, 2003·Journal of General Internal Medicine·Jeffrey A Linder, Daniel E Singer
May 12, 2006·Depression and Anxiety·Sonya B NormanMurray B Stein
Feb 20, 2007·Journal of Substance Abuse Treatment·Errol YudkoAdriana Fouts
Jul 31, 2007·The Journal of Allergy and Clinical Immunology·Silvano DragonieriPeter J Sterk
Oct 1, 2009·BMC Cancer·Amel BajtarevicAnton Amann
Feb 22, 2012·Sensors·Alphus D Wilson, Manuela Baietto
Sep 21, 2012·Chemical Reviews·Meggie HakimHossam Haick
Sep 7, 2013·Chest·Pablo Martinez-Lozano SinuesMalcolm Kohler
Jan 15, 2014·Journal of Breath Research·B de Lacy CostelloN M Ratcliffe
Apr 1, 2014·Journal of Cheminformatics·Damjan KrstajicSimon Thomas
Jun 3, 2014·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Ana F TruebaThomas Ritz
Jun 25, 2014·Metabolites·Célia Lourenço, Claire Turner
Mar 17, 2015·IEEE Transactions on Bio-medical Engineering·Annette McWilliamsCalum E MacAulay
May 7, 2015·Journal of Breath Research·Tomasz LigorBogusław Buszewski
Jul 15, 2015·PloS One·Jan-Philipp BachAndreas Rembert Koczulla
Sep 9, 2015·Annals of the American Thoracic Society·Thomas RitzDavid Rosenfield
Sep 26, 2015·Nature Neuroscience·Robert M Sapolsky
Nov 6, 2015·Sensors·Jia YanSonglin Zhang
Dec 15, 2015·Journal of Breath Research·S GhimentiF Di Francesco
Dec 17, 2015·Journal of Breath Research·Jan Hendrik LeopoldAmeen Abu-Hanna
Jun 23, 2016·Journal of Chiropractic Medicine·Terry K Koo, Mae Y Li
Feb 27, 2017·Lung·Silvano DragonieriOnofrio Resta
Apr 28, 2017·The European Respiratory Journal·Ildiko HorváthTeunis J Vink
Aug 13, 2017·Journal of Bioscience and Bioengineering·Emi TakeoEiichiro Fukusaki
Oct 25, 2017·Cancer Biomarkers : Section a of Disease Markers·Ingrid Oakley-Girvan, Sharon Watkins Davis
May 16, 2018·International Journal of Psychology : Journal International De Psychologie·Alessandro TonacciRaffaele Conte
Mar 18, 2019·Psychiatry Research·Magnus SjögrenJitka Stilund Hansen

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Methods Mentioned

BETA
PCA

Software Mentioned

nose
R
Python

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