Machine Learning Applications in Head and Neck Radiation Oncology: Lessons From Open-Source Radiomics Challenges

Frontiers in Oncology
Hesham ElhalawaniClifton D Fuller

Abstract

Radiomics leverages existing image datasets to provide non-visible data extraction via image post-processing, with the aim of identifying prognostic, and predictive imaging features at a sub-region of interest level. However, the application of radiomics is hampered by several challenges such as lack of image acquisition/analysis method standardization, impeding generalizability. As of yet, radiomics remains intriguing, but not clinically validated. We aimed to test the feasibility of a non-custom-constructed platform for disseminating existing large, standardized databases across institutions for promoting radiomics studies. Hence, University of Texas MD Anderson Cancer Center organized two public radiomics challenges in head and neck radiation oncology domain. This was done in conjunction with MICCAI 2016 satellite symposium using Kaggle-in-Class, a machine-learning and predictive analytics platform. We drew on clinical data matched to radiomics data derived from diagnostic contrast-enhanced computed tomography (CECT) images in a dataset of 315 patients with oropharyngeal cancer. Contestants were tasked to develop models for (i) classifying patients according to their human papillomavirus status, or (ii) predicting local tumo...Continue Reading

References

Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Nov 1, 2011·Journal of Digital Imaging·John B FreymannC Carl Jaffe
Nov 21, 2012·Nature Reviews. Clinical Oncology·Philippe LambinAndre Dekker
May 26, 2015·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Xenia FaveLaurence Court
Jun 27, 2015·Investigative Radiology·Dennis MackinLaurence Court
Jul 15, 2015·Journal of Medical Imaging·Samuel G ArmatoLaurence P Clarke
Nov 3, 2016·Nature Reviews. Clinical Oncology·James P B O'ConnorJohn C Waterton
Jan 24, 2017·Medical Physics·Muhammad Shafiq-Ul-HassanEduardo Gerardo Moros
Feb 17, 2017·IEEE Transactions on Medical Imaging·Bulat IbragimovTomaz Vrtovec
Jul 5, 2017·Scientific Data·UNKNOWN MICCAI/M.D. Anderson Cancer Center Head and Neck Quantitative Imaging Working Group
Jul 26, 2017·Advances in Radiation Oncology·Charles S MayoRandall K Ten Haken
Aug 12, 2017·Tomography : a Journal for Imaging Research·Keyvan FarahaniNola Hylton
Jan 26, 2018·Scientific Reports·UNKNOWN M. D. Anderson Cancer Center Head and Neck Quantitative Imaging Working Group
Feb 1, 2018·Journal of Radiation Research·Jia WuRuijiang Li
Feb 7, 2018·Scientific Reports·Dennis MackinLaurence Court
Feb 28, 2018·International Journal of Radiation Oncology, Biology, Physics·Charles S MayoTorunn I Yock
Mar 30, 2018·Clinical and Translational Radiation Oncology·Kaixian YuHongtu Zhu
Aug 1, 2016·Translational Cancer Research·Andrew J WongClifton D Fuller

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Citations

Aug 1, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Tricia ChinneryPencilla Lang
Oct 22, 2019·European Journal of Immunology·Andrea CossarizzaArturo Zychlinsky
Jun 22, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Luca CozziMarta Scorsetti
Jul 31, 2020·Frontiers of Medicine·Ke Sheng
Nov 12, 2020·Abdominal Radiology·S NougaretE Sala
Jun 24, 2019·BJR Open·Michela GabelloniEmanuele Neri
Nov 24, 2020·Physics in Medicine and Biology·Harald PaganettiTony Lomax
Mar 16, 2021·European Journal of Radiology·Renato CuocoloMassimo Imbriaco
Mar 30, 2021·Radiology. Imaging Cancer·Lu WangJiangdian Song
Apr 22, 2021·The British Journal of Radiology·Morgan MichaletStéphanie Nougaret
Jun 15, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Andrew WentzelUNKNOWN Spatial-Non-spatial Multi-Dimensional Analysis of Radiotherapy Treatment/Toxicity Team SMART3

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Methods Mentioned

BETA
feature extraction

Software Mentioned

Kaggle
Class
R
Clinical Trial Processor
radiomics
MATLAB
DICOM
RT
Imaging Biomarker Explorer ( IBEX )
VelocityGrid

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