Machine learning classifiers and fMRI: a tutorial overview

Francisco PereiraMatthew Botvinick


Interpreting brain image experiments requires analysis of complex, multivariate data. In recent years, one analysis approach that has grown in popularity is the use of machine learning algorithms to train classifiers to decode stimuli, mental states, behaviours and other variables of interest from fMRI data and thereby show the data contain information about them. In this tutorial overview we review some of the key choices faced in using this approach as well as how to derive statistically significant results, illustrating each point from a case study. Furthermore, we show how, in addition to answering the question of 'is there information about a variable of interest' (pattern discrimination), classifiers can be used to tackle other classes of question, namely 'where is the information' (pattern localization) and 'how is that information encoded' (pattern characterization).


Feb 1, 1997·Artificial Intelligence in Medicine·G F CooperP Spirtes
May 18, 1999·NeuroImage·L K HansenO B Paulson
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Sep 11, 2003·Journal of Cognitive Neuroscience·Thomas A CarlsonSheng He
Oct 27, 2004·NeuroImage·Anthony Randal McIntosh, Nancy J Lobaugh
Apr 15, 2005·Journal of Cognitive Neuroscience·Alice J O'TooleJames V Haxby
Apr 27, 2005·Nature Neuroscience·Yukiyasu Kamitani, Frank Tong
Jul 30, 2005·Current Biology : CB·John-Dylan Haynes, Geraint Rees
Dec 24, 2005·Science·Sean M PolynKenneth A Norman
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Nikolaus KriegeskortePeter Bandettini
Mar 30, 2006·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Stephen C Strother
Jun 23, 2006·Nature Reviews. Neuroscience·John-Dylan Haynes, Geraint Rees
Aug 11, 2006·Trends in Cognitive Sciences·Kenneth A NormanJames V Haxby
Mar 23, 2007·NeuroImage·Geoffrey Karl Aguirre
Aug 21, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Aurélie KasPhilippe Remy
May 31, 2008·Science·Tom M MitchellMarcel Adam Just

❮ Previous
Next ❯


Oct 19, 2011·Journal of Medical Systems·S Issac NiwasW J Zhang
Apr 1, 2013·Psychometrika·Firdaus JanoosWilliam M Wells
Feb 19, 2013·Neuroinformatics·J SchrouffJ Mourão-Miranda
Jul 27, 2012·Neuroscience Bulletin·Zhi YangXuchu Weng
Jul 23, 2013·Brain and Cognition·Julia BenderClayton E Curtis
Mar 19, 2013·Neuropsychologia·Greg J DetreKenneth A Norman
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Valeria GazzolaChristian Keysers
Mar 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Chun Siong SoonJohn-Dylan Haynes
Aug 6, 2011·Cerebral Cortex·Carlo ReverberiJohn-Dylan Haynes
May 23, 2012·Cerebral Cortex·Jörn DiedrichsenJohn W Krakauer
Sep 11, 2010·Science·Nico U F DosenbachBradley L Schlaggar
Oct 26, 2012·Computational Intelligence and Neuroscience·E W LangC G Puntonet
Jan 28, 2011·Journal of Cognitive Neuroscience·Susanne QuadfliegC Neil Macrae
Sep 16, 2011·Journal of Cognitive Neuroscience·Kenji Ogawa, Toshio Inui
Oct 1, 2011·Journal of Cognitive Neuroscience·Jarrod A Lewis-PeacockBradley R Postle
Jan 10, 2012·Journal of Cognitive Neuroscience·Rajeev D S Raizada, Andrew C Connolly
Dec 4, 2012·Journal of Cognitive Neuroscience·Joshua J LaRocqueBradley R Postle
Aug 7, 2013·Journal of Cognitive Neuroscience·Jelmer P BorstJohn R Anderson
Jan 24, 2013·Neural Computation·Yusuke FujiwaraYukiyasu Kamitani
Jun 1, 2011·PLoS Computational Biology·Emili Balaguer-BallesterDaniel Durstewitz
Jul 7, 2011·PLoS Computational Biology·Kay H BrodersenKlaas E Stephan
Nov 15, 2011·PloS One·Rongjun YuLin Lu
Dec 17, 2011·PloS One·Marzia De LuciaSophie Schwartz
Aug 1, 2012·PloS One·Laura N Van der LaanPaul A M Smeets
Oct 17, 2012·PloS One·Mona SobhaniLisa Aziz-Zadeh
Jun 5, 2013·PloS One·John M HendersonJenn Olejarczyk
Jun 21, 2013·PloS One·João CastelhanoMiguel Castelo-Branco

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