Machine learning for direct oxygen saturation and hemoglobin concentration assessment using diffuse reflectance spectroscopy.

Journal of Biomedical Optics
Ingemar FredrikssonTomas Strömberg

Abstract

Diffuse reflectance spectroscopy (DRS) is frequently used to assess oxygen saturation and hemoglobin concentration in living tissue. Methods solving the inverse problem may include time-consuming nonlinear optimization or artificial neural networks (ANN) determining the absorption coefficient one wavelength at a time. To present an ANN-based method that directly outputs the oxygen saturation and the hemoglobin concentration using the shape of the measured spectra as input. A probe-based DRS setup with dual source-detector separations in the visible wavelength range was used. ANNs were trained on spectra generated from a three-layer tissue model with oxygen saturation and hemoglobin concentration as target. Modeled evaluation data with realistic measurement noise showed an absolute root-mean-square (RMS) deviation of 5.1% units for oxygen saturation estimation. The relative RMS deviation for hemoglobin concentration was 13%. This accuracy is at least twice as good as our previous nonlinear optimization method. On blood-intralipid phantoms, the RMS deviation from the oxygen saturation derived from partial oxygen pressure measurements was 5.3% and 1.6% in two separate measurement series. Results during brachial occlusion showed ex...Continue Reading

References

Apr 10, 2003·Journal of Biomedical Optics·T Joshua PfeferMarwood N Ediger
Aug 19, 2009·Optics Express·Sheng-Hao TsengNikiforos Kollias
Dec 1, 2009·Journal of Biophotonics·Nikiforos KolliasPaulo R Bargo
May 9, 2012·Journal of Biomedical Optics·Ingemar FredrikssonTomas Strömberg
Jun 29, 2012·Biomedical Optics Express·Quanzeng WangJoshua Pfefer
Feb 22, 2013·Journal of Biomedical Optics·Maxim E DarvinJuergen Lademann
May 15, 2013·Physics in Medicine and Biology·Steven L Jacques
Apr 3, 2014·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Katarzyna Z KuligaGeraldine F Clough
May 10, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Hanna JonassonTomas Strömberg
Nov 16, 2017·Journal of Biomedical Optics·Ingemar FredrikssonTomas Strömberg
Jan 25, 2019·Journal of Biomedical Optics·Ingemar FredrikssonMarcus Larsson
Mar 7, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Hanna JonassonTomas Strömberg

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Citations

Nov 11, 2021·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Ingemar FredrikssonFredrik Iredahl

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EPOS
Matlab
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