Machine Learning of DTI Structural Brain Connectomes for Lateralization of Temporal Lobe Epilepsy

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
Kouhei KamiyaKuni Ohtomo

Abstract

We analyzed the ability of a machine learning approach that uses diffusion tensor imaging (DTI) structural connectomes to determine lateralization of epileptogenicity in temporal lobe epilepsy (TLE). We analyzed diffusion tensor and 3-dimensional (3D) T1-weighted images of 44 patients with TLE (right, 15, left, 29; mean age, 33.0 ± 11.6 years) and 14 age-matched controls. We constructed a whole brain structural connectome for each subject, calculated graph theoretical network measures, and used a support vector machine (SVM) for classification among 3 groups (right TLE versus controls, left TLE versus controls, and right TLE versus left TLE) following a feature reduction process with sparse linear regression. In left TLE, we found a significant decrease in local efficiency and the clustering coefficient in several brain regions, including the left posterior cingulate gyrus, left cuneus, and both hippocampi. In right TLE, the right hippocampus showed reduced nodal degree, clustering coefficient, and local efficiency. With use of the leave-one-out cross-validation strategy, the SVM classifier achieved accuracy of 75.9 to 89.7% for right TLE versus controls, 74.4 to 86.0% for left TLE versus controls, and 72.7 to 86.4% for left TL...Continue Reading

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Citations

Nov 21, 2017·Nihon Hoshasen Gijutsu Gakkai zasshi·Masami Goto
Sep 4, 2019·Epilepsia·Bardia Abbasi, Daniel M Goldenholz
Nov 9, 2018·Scientific Reports·Issei UedaYukunori Korogi
Dec 1, 2018·Japanese Journal of Radiology·Koji Sakai, Kei Yamada
Sep 5, 2020·Network Neuroscience·Ahmad MheichMahmoud Hassan
May 30, 2020·Human Brain Mapping·Sanjay M SisodiyaUNKNOWN ENIGMA Consortium Epilepsy Working Group
Nov 26, 2020·Epilepsia·Sara LarivièreBoris C Bernhardt
Jul 10, 2021·Frontiers in Neuroscience·Daichi Sone, Iman Beheshti
Aug 3, 2021·NeuroImage. Clinical·Ezequiel GleichgerrchtUNKNOWN ENIGMA-Epilepsy Working Group
Nov 3, 2020··Sovanlal MukherjeeJulia Wallace

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