macho-1-Related genes in Ciona embryos

Development Genes and Evolution
Yutaka SatouNori Satoh

Abstract

In ascidians, maternal factor(s) localized in the myoplasm of the egg are essential for specification and subsequent differentiation of larval muscle cells. The macho-1 gene of Halocynthia roretzi encodes a zinc-finger protein: the gene is only expressed maternally, the resultant maternal mRNA is localized to the myoplasm, and the gene function is essential for muscle cell differentiation. Here we have characterized macho-1 homologues, Ci-macho1 of Ciona intestinalis and Cs-macho1 of Ciona savignyi. Interestingly, we found that the Ciona macho-1 genes are expressed both maternally and zygotically: their maternal transcript is localized to the myoplasm while their zygotic expression is seen after neurulation in cells of the central nervous system. Functional suppression of Cs-macho1 with morpholino antisense oligonucleotide resulted in inhibition of the initiation of zygotic expression of a muscle-specific actin gene. We propose a possible evolutionary scenario in which an ancestral Zic-related gene gave rise to both the macho-1-like muscle determinant gene as well as neuronal Zic genes.

Citations

May 9, 2003·Development Genes and Evolution·Yutaka SatouNori Satoh
Oct 8, 2004·Nature·William R JefferyYoshiyuki Yamamoto
Dec 17, 2004·Biology of the Cell·Christian SardetFrançois Prodon
Jun 10, 2006·International Journal of Biological Sciences·Hiroshi Wada, Kaz Makabe
Feb 28, 2013·Cellular and Molecular Life Sciences : CMLS·Rob HoutmeyersRuth Arkell
Jul 16, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Naohito TakatoriHiroki Takahashi
Mar 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·François ProdonYasunori Sasakura
Mar 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gaku Kumano, Hiroki Nishida
Apr 11, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christian SardetJanet Chenevert
Apr 17, 2008·Biology of the Cell·Clare Hudson, Hitoyoshi Yasuo
Jun 23, 2004·Molecular and Cellular Neurosciences·Jun Aruga
Jul 1, 2014·Genesis : the Journal of Genetics and Development·William R Jeffery
Sep 15, 2004·Developmental Cell·Daniel Meulemans, Marianne Bronner-Fraser
Sep 24, 2004·Developmental Biology·Kasumi YagiYutaka Satou
Sep 9, 2009·Developmental Biology·Alexandre PaixChristian Sardet
Dec 21, 2005·Developmental Biology·James A ListerDavid W Raible
Sep 24, 2004·Developmental Biology·Jr-Kai YuLinda Z Holland
Mar 15, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yale J Passamaneck, Anna Di Gregorio
Jun 24, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hiroki Nishida
Mar 5, 2020·Development, Growth & Differentiation·Boqi Liu, Yutaka Satou
Mar 10, 2015·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Yutaka Satou, Kaoru S Imai
Jun 30, 2019·EvoDevo·Florian Razy-Krajka, Alberto Stolfi
Apr 30, 2004·Development·Yutaka SatouNori Satoh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.