MACOP-B treatment for advanced stage diffuse large cell lymphoma: a multicenter Italian Study.

European Journal of Cancer & Clinical Oncology
U VitoloG Luxi

Abstract

Seventy-one patients with advanced stage diffuse large cell lymphoma were treated with MACOP-B. Sixty-nine per cent of patients achieved a complete response (CR), 10% a partial remission, while 11% had no response and 10% died because of toxicity. The CR rate was adversely affected by immunoblastic type, poor performance status and bone marrow involvement. Two-year survival for all 71 patients was 55% and 2-year disease-free survival (DFS) for the 49 CRs was 73%. Relapses were lower (P less than 0.05) in patients achieving CR in 8 weeks or less (DFS 83% vs. 59%) and in patients without tumor bulk (DFS 87% vs. 54%). Overall toxicity was acceptable with mucositis proving to be the most frequent severe side-effect. However, treatment-related deaths were unacceptably high in patients over 59 years of age (30% vs. 7%). Thus for the elderly MACOP-B is potentially lethal and must be used cautiously. These preliminary results confirm the effectiveness of MACOP-B. The delay of response and/or the presence of tumor bulk may be important prognostic factors in identifying a subset of poor risk patients with a high incidence of relapse.

Citations

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·C MarosiI Schwarzinger
Apr 4, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Lale Kostakoglu
Jan 1, 1992·Acta Oncologica·H Joensuu, T Turpeenniemi-Hujanen

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