Macro-architectures in spinal cord scaffold implants influence regeneration.

Journal of Neurotrauma
Darice Y WongFrank Lamarca

Abstract

Biomaterial scaffold architecture has not been investigated as a tunable source of influence on spinal cord regeneration. This study compared regeneration in a transected spinal cord within various designed-macro-architecture scaffolds to determine if these architectures alone could enhance regeneration. Three-dimensional (3-D) designs were created and molds were built on a 3-D printer. Salt-leached porous poly(epsilon-caprolactone) was cast in five different macro-architectures: cylinder, tube, channel, open-path with core, and open-path without core. The two open-path designs were created in this experiment to compare different supportive aspects of architecture provided by scaffolds and their influence on regeneration. Rats received T8 transections and implanted scaffolds for 1 and 3 months. Overall morphology and orientation of sections were characterized by H&E, luxol fast blue, and cresyl violet staining. Borders between intact gray matter and non-regenerated defect were observed from GFAP immunolabeling. Nerve fibers and regenerating axons were identified with Tuj-1 immunolabeling. The open-path designs allowed extension of myelinated fibers along the length of the defect both exterior to and inside the scaffolds and mai...Continue Reading

References

May 1, 1991·Trends in Neurosciences·H Thoenen
Apr 1, 1994·Journal of Neural Transplantation & Plasticity·J D Houle, M K Ziegler
Jun 26, 1999·The European Journal of Neuroscience·M OudegaM B Bunge
Feb 9, 2002·Science·Martin E Schwab
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yang D TengEvan Y Snyder
Aug 10, 2002·The European Journal of Neuroscience·Sibille KaegiKarim Fouad
Aug 22, 2002·Neurosurgery·Jonathan A FriedmanMichael J Yaszemski
Jul 11, 2003·Biomaterials·Lauren FlynnMolly S Shoichet
Oct 16, 2003·Spine·Satoru YoshiiAtaru Taniguchi
Nov 19, 2003·Current Opinion in Neurology·Liudmila N NovikovaJan-Olof Kellerth
Aug 13, 2004·Journal of Biomedical Materials Research. Part a·Satoru YoshiiMasao Akagi
May 24, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Yi-Cheng HuangHwa-Chang Liu
Jun 18, 2005·Brain Research. Brain Research Reviews·Ning ZhangXuejun Wen
Aug 24, 2005·Biomaterials·Joshua S GoldnerDiane Hoffman-Kim
Oct 18, 2005·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Satoru FukunagaSouji Maruo
Feb 1, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Terrance W Carone, Julie M Hasenwinkel
Feb 21, 2006·Progress in Neurobiology·Jan M SchwabHermann J Schluesener
Apr 25, 2006·Journal of Neurotrauma·Hiroshi NomuraMolly S Shoichet
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Irin C Maier, Martin E Schwab
Oct 20, 2006·Expert Opinion on Biological Therapy·Tessa Hadlock, Cathryn Sundback
Oct 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·A W BarrittE J Bradbury
Nov 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Abderrahman El MaaroufUrs Rutishauser
Jan 16, 2007·Current Opinion in Neurobiology·Sarah A Busch, Jerry Silver
Mar 8, 2007·Nature Clinical Practice. Neurology·Susan C Barnett, John S Riddell
Apr 25, 2007·Journal of Nanoscience and Nanotechnology·Fabrizio GelainShuguang Zhang
May 24, 2007·Tissue Engineering·Shula StokolsMark H Tuszynski

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Citations

Mar 9, 2012·Regenerative Medicine·Sárka Kubinová, Eva Syková
May 26, 2012·Nanomedicine·Jacqueline Li-Ling KuehRobert Stevens
Nov 5, 2014·Neural Regeneration Research·Christian B RicksRamesh Grandhi
Aug 1, 2009·Stem Cell Reviews and Reports·Peter A WalkerCharles S Cox
Dec 4, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Laura De LaporteLonnie D Shea
Jul 3, 2013·Pharmacological Reviews·George J ChristKarl-Erik Andersson
Jul 20, 2011·Journal of Materials Science. Materials in Medicine·Daniel LynamJeffrey S Sakamoto
Jun 7, 2013·Interface Focus·Xiumei WangFu-Zhai Cui
Feb 23, 2011·Tissue Engineering. Part B, Reviews·Mindan WangFuzhai Cui
Jul 25, 2012·Cell Biochemistry and Biophysics·Manuel Pérez-GarnésManuel Monleón Pradas
Jan 29, 2016·Journal of Neuroscience Methods·Dylan A McCreedyLonnie D Shea
Jul 19, 2012·Journal of Cellular and Molecular Medicine·Ana Paula PêgoEva Sykova
Aug 21, 2013·Journal of Tissue Engineering and Regenerative Medicine·Raymond J ColelloDavid G Simpson
Sep 22, 2009·Journal of Biomedical Materials Research. Part a·Afra Hadjizadeh, Davod Mohebbi-Kalhori
Jan 28, 2016·Regenerative Biomaterials·Liliana R Pires, Ana P Pêgo
Apr 24, 2012·Biomaterials·Mehdi NikkhahAli Khademhosseini
Mar 4, 2014·PloS One·Daniela Nogueira RochaAna Paula Pêgo
Feb 27, 2019·Journal of Tissue Engineering and Regenerative Medicine·Jeffrey S HakimNicolas N Madigan
Mar 25, 2019·Journal of Biomedical Materials Research. Part a·Yan SunXiao-Hong Li
May 23, 2019·Journal of Biomedical Materials Research. Part a·Michael J TaylorLara J Gamble
Jan 16, 2019·Nature Medicine·Jacob KofflerMark H Tuszynski
Apr 10, 2019·Neural Regeneration Research·Shuo LiuBin Wang
Feb 11, 2020·Advanced Functional Materials·Daeha JoungMichael C McAlpine
Nov 18, 2020·Advanced Healthcare Materials·Melissa CadenaSteven A Sloan
Feb 3, 2019·Acta Biomaterialia·Qingzheng ZhangXuesi Chen
Jul 10, 2017·ACS Biomaterials Science & Engineering·Bridget A BreenSiobhan S McMahon
Dec 16, 2020·ACS Biomaterials Science & Engineering·Walaa A AbbasNageh K Allam

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Methods Mentioned

BETA
scanning electron microscopy

Software Mentioned

Rhinoceros
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