PMID: 7537158Mar 1, 1995Paper

Macroamylasemia: a possible cause of unexplained hyperamylasemia in rheumatoid arthritis

British Journal of Rheumatology
M CutoloS Accardo

Abstract

Macroamylasemia is a benign acquired condition, characterized by a serum amylase unusually large in molecular size that has been found to occur in apparently healthy humans as well as in a variety of diseases including liver disease, diabetes, cancer malabsorption and autoimmune disorders. Most commonly macroamylasemia results from the formation of immune complexes between amylase and immunoglobulins. We describe the first case of an association between macroamylasemia/hyperamylasemia and rheumatoid arthritis characterized by the absence of immunoglobulins, as amylase binding globulins, within the macroamylase complex. Failure to identify macroamylase as the cause of unexplained but benign hyperamylasemia correctly, can lead to costly studies (e.g. ultrasonography, computerized tomography) to rule out pancreatic disease, and could induce prescription of unnecessary elemental diets and replacement therapies, as reported in our patient.

Citations

Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·S R Davis
Dec 30, 2014·Biochimica Et Biophysica Acta·Takanori MoriyamaNaoyuki Honma
Apr 24, 2001·The American Journal of Gastroenterology·A RabsztynK Horvath

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Journal of Clinical Gastroenterology
S KatzB Napolitano
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine
S OkadaI Sakurabayashi
Scandinavian Journal of Clinical and Laboratory Investigation
G BonettiR Moratti
© 2021 Meta ULC. All rights reserved